Study type: Medical/biological study (experimental study)

Mobile phone-induced myocardial oxidative stress: protection by a novel antioxidant agent caffeic acid phenethyl ester. med./bio.

Published in: Toxicol Ind Health 2005; 21 (9): 223-230

Aim of study (acc. to author)

To study 900 MHz mobile phone-induced oxidative stress that promotes production of reactive oxygen species and the role of CAPE on myocardial tissue against possible oxidative damage in rats.

Background/further details

Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis. It has been used in folk medicine for many years in Middle East countries. It was found to be a potent free radical scavenger and antioxidant.
CAPE (10 µM/ml per kg per day) were administered daily for 10 days to the animals prior to their daily electromagnetic field exposure.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: repeated daily exposure, 30 min/day for 10 days

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration repeated daily exposure, 30 min/day for 10 days
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
Exposure setup
Exposure source
Chamber A special exposure device with six exposure antennas for insulated exposure was used.
Setup Rats were individually placed in a ventilated plastic tube cage (12 cm long x 5 cm in diameter) with their heads positioned in close contact above a half-wave dipole antenna.
Sham exposure A sham exposure was conducted.
Additional info Animals were randomly grouped as follows: sham-operated control rats, 900 MHz EMF exposed rats and 900 MHz EMF exposed + CAPE-treated rats, injected daily i.p. with CAPE before exposure. Control rats received an equal volume of isotonic saline solution. All rats were anaesthetized with pentobarbital Na before exposure.
Parameters
Measurand Value Type Method Mass Remarks
power 2 W peak value - - -
power density 1.04 mW/cm² - measured - -
SAR 4 W/kg - measured - locally in the head
SAR 0.016 W/kg - measured whole body -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In the electromagnetic field exposed group, while tissue malondialdehyde and nitric oxide levels increased, superoxide dismutase, catalase and glutathione peroxidase activities were reduced. CAPE treatment reversed these effects.
The data demonstrate the role of oxidative mechanisms in 900 MHz mobile phone-induced heart tissue damage, and CAPE, via its free radical scavenging and antioxidant properties, ameliorates oxidative heart injury. These findings show that CAPE exhibits a protective effect on mobile phone-induced and free radical mediated oxidative heart impairment in rats.

Study character:

Study funded by

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