Study type: Medical/biological study (experimental study)

Modulation of heat shock protein response in SH-SY5Y by mobile phone microwaves. med./bio.

Published in: World J Biol Chem 2012; 3 (2): 34-40

Aim of study (acc. to author)

To study the effects of radiofrequency exposure on the stress response in neuroblastoma cells, differentiated to dopaminergic neuron-like cells (induced by retinoic acid).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 1,760 MHz
Exposure duration: continuous for 2 h and 4 h

Exposure 1

Main characteristics
Frequency 1,760 MHz
Type
Exposure duration continuous for 2 h and 4 h
Exposure setup
Exposure source
Distance between exposed object and exposure source 3 cm
Sham exposure A sham exposure was conducted.
Additional info no increase of temperature was measured around the cultures during exposure
Parameters
Measurand Value Type Method Mass Remarks
SAR 0.086 W/kg - calculated - average
electric field strength 25 V/m maximum measured - -
magnetic field strength 66 mA/m maximum measured - -
power density 1.7 W/m² maximum measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

Under these experimental conditions, neither apoptosis nor Hsp27 expression nor caspase 3 expression were significantly changed following exposure. However, a significant decrease in Hsp20 expression was found at both times of exposure (2 and 4 h), whereas Hsp70 levels were significantly increased only after 4 h exposure (according to the abstract; within the results section, the authors also demonstrate a significant increase after the 2 h exposure compared with the sham exposed cells, remark EMF-Portal). Additionally, p-Hsp27 (phosphorylated Hsp27) expression was significantly increased in the exposed cells compared with the controls.
Remark EMF-Portal: The data on the cell viability are not clearly documented according to significance (in the abstract and discussion section: no change; within the results section: decrease), c.f. full text link.
The changes in the expression of the heat shock proteins in neuronal cells could be an early response to the microwave exposure.

Study character:

Study funded by

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