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To study the effects of radiofrequency exposure on the stress response in neuroblastoma cells, differentiated to dopaminergic neuron-like cells (induced by retinoic acid).
|ばく露時間||continuous for 2 h and 4 h|
|Distance between exposed object and exposure source||3 cm|
|Sham exposure||A sham exposure was conducted.|
|Additional information||no increase of temperature was measured around the cultures during exposure|
Under these experimental conditions, neither apoptosis nor Hsp27 expression nor caspase 3 expression were significantly changed following exposure. However, a significant decrease in Hsp20 expression was found at both times of exposure (2 and 4 h), whereas Hsp70 levels were significantly increased only after 4 h exposure (according to the abstract; within the results section, the authors also demonstrate a significant increase after the 2 h exposure compared with the sham exposed cells, remark EMF-Portal). Additionally, p-Hsp27 (phosphorylated Hsp27) expression was significantly increased in the exposed cells compared with the controls.
Remark EMF-Portal: The data on the cell viability are not clearly documented according to significance (in the abstract and discussion section: no change; within the results section: decrease), c.f. full text link.
The changes in the expression of the heat shock proteins in neuronal cells could be an early response to the microwave exposure.