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Medical/biological study (experimental study)

The prophylactic effect of vitamin C on induced oxidative stress in rat testis following exposure to 900 MHz radio frequency wave generated by a BTS antenna model.

Published in: Electromagn Biol Med 2013; 32 (3): 409-416

Aim of study (acc. to author)

The effects of exposure of rats to a 900 MHz electromagnetic field on oxidative stress in the testes and the protective effect of vitamin C should be investigated.
Background/further details: Rats were divided into 4 groups (n=8 each): 1) exposure: exposure to the electromagnetic field and daily sham administration (orally, distilled water), 2) exposure + vitamin C: exposure to the electromagnetic field and daily administration of vitamin C (orally, 200 mg/kg body weight), 3) vitamin c: sham exposure and daily administration of vitamin C, 4) sham exposure: sham exposure and daily sham administration.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 4 h/day for 45 days
Exposure 1
Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 4 h/day for 45 days
Exposure setup
Exposure source
Distance between exposed object and exposure source 5 m
Chamber cage
Setup 8 animals per cage
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power density 0.6789 mW/cm² - measured - -
Additional parameter details
the power of the antenna at the location of the animal cage in the experiment equalized the power at the minimum distance of a citizen's residence (17 m) to a base station (=-75 db)
Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In the exposure group (group 1), the enzyme activities of the superoxide dismutase, glutathione peroxidase and catalase were significantly decreased and the lipid peroxidation was significantly increased compared to the other groups.
In the exposure + vitamin c group (group 2), the enzyme activity of superoxide dismutase was significantly increased compared to the other groups and lipid peroxidation was significantly lower than in the exposure group, but still significantly increased compared to the non-exposed groups (groups 3 and 4). All other parameters did not show any significant differences in group 2 compared to the non-exposed groups.
No significant differences were found between the vitamin c group and sham exposure group (groups 3 and 4).
The authors conclude that exposure of rats to a 900 MHz electromagnetic field could induce oxidative stress in the testes and that vitamin C might improve antioxidant enzyme activity.
Study character:

Study funded by

  • not stated/no funding

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