Study type: Medical/biological study (experimental study)

Vitamin C protects rat cerebellum and encephalon from oxidative stress following exposure to radiofrequency wave generated by a BTS antenna model. med./bio.

Published in: Toxicol Mech Methods 2014; 24 (5): 347-352

Aim of study (acc. to author)

The effects of exposure of rats to a 900 MHz electromagnetic field on oxidative stress in the testes and the protective effect of vitamin C should be investigated.

Background/further details

(Remark EMF-Portal: the term "encephalon" as used in the article probably describes only the cerebrum, as the cerebellum was investigated separately.)
Rats were divided into 4 groups (n=8 each): 1) exposure: exposure to the electromagnetic field and daily sham administration (orally, distilled water), 2) exposure + vitamin C: exposure to the electromagnetic field and daily administration of vitamin C (orally, 200 mg/kg body weight), 3) vitamin c: sham exposure and daily administration of vitamin C, 4) sham exposure: sham exposure and daily sham administration.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Exposure duration: continuous for 4 h/day for 45 days

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 4 h/day for 45 days
Exposure setup
Exposure source
Distance between exposed object and exposure source 5 m
Chamber cage
Setup 8 animals per cage
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power density 0.6789 mW/cm² - - - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

In the cerebellum and "encephalon" of the exposure group (group 1), the enzyme activities of the superoxide dismutase, glutathione peroxidase and catalase were significantly decreased and the lipid peroxidation was significantly increased compared to the other groups.
No significant differences were found between the exposure + vitamin c group, vitamin c group and sham exposure group (groups 2, 3 and 4).
The authors conclude that exposure of rats to a 900 MHz electromagnetic field could induce oxidative stress in the brain and vitamin C might improve antioxidant enzyme activity and reduce the lipid peroxidation.

Study character:

Study funded by

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