研究のタイプ: 医学/生物学の研究 (experimental study)

[アルツハイマー病および筋萎縮性側索硬化症のマウスモデルにおいて低周波磁界は病状を悪化させない] med./bio.

Low-frequency magnetic fields do not aggravate disease in mouse models of Alzheimer's disease and amyotrophic lateral sclerosis.

掲載誌: Sci Rep 2015; 5: 8585

この研究は、確立されたアルツハイマー病(AD)および筋萎縮性側索硬化症(ALS)のマウスモデルであるAPP23マウスおよびSOD1マウスに、低周波磁界LF-MF:50 Hz、1 mT)の長期ばく露(16ヶ月)を与え、学習障害、生存率などへの影響を調べた。その結果、APP23マウスの学習障害は長期ばく露によって悪化しなかった;SOD1マウスでの発病および生存率への影響も見られなかった、と報告している。

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研究目的(著者による)

The effects of a chronic exposure of mice to a 50 Hz magnetic field on the development of Alzheimer's disease and amyotrophic lateral sclerosis should be investigated.

詳細情報

APP23 mice with an overexpression of the amyloid precursor protein (APP) were used as a model for early onset of Alzheimer's disease. SOD1G85R and SODG93A mice with an overexpression of mutant superoxide dismutase 1 (SOD-1) were used as models for amyotrophic lateral sclerosis. SOD1WT mice, overexpressing human wild type SOD-1, were used as negative controls for the SOD mutation. All mice were 2 month old when the experiment started.
The following groups were used: 1) APP23 mice exposed to the magnetic field (n=?), 2) sham exposed APP23 mice (n=?), 3) SOD1G85R mice exposed to the magnetic field (n=135), 4) sham exposed SOD1G85R mice (n=138), 5) SOD1G93A mice exposed to the magnetic field (n=122), 6) sham exposed SOD1G93A mice (n=110), 7) non-exposed SOD1WT mice (n=?), 8) non-exposed non-transgenic littermates (n=?).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 50 Hz
ばく露時間: continuous for 16 months

ばく露1

主たる特性
周波数 50 Hz
タイプ
  • magnetic field
ばく露時間 continuous for 16 months
ばく露装置
ばく露の発生源/構造
チャンバの詳細 cages without metal
ばく露装置の詳細 several mouse cages were placed in one module on three levels within the homogeneous field; Merritt coils consisted of two coils of 26 and 11 turns each which were connected in series; the cable consisted of five wires with a total cross-section area of 16 mm2; wires were wrapped in aluminum foil to block electric fields; exposure units were shielded to prevent fringing
Sham exposure A sham exposure was conducted.
Additional information modules for sham exposure looked identical to the modules for exposure, but wires were turned after half of the turns
パラメータ
測定量 種別 Method Mass 備考
磁束密度 1 mT - 測定値 - -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

No significant differences were found in any parameter between exposed and sham exposed animals of all strains, respectively.
The authors conclude that chronic exposure of mice to a 50 Hz magnetic field has no effects on the development, course or symptoms of Alzheimer's disease and amyotrophic lateral sclerosis.

研究の種別:

研究助成

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