研究のタイプ: 医学/生物学の研究 (experimental study)

[ヒトの赤血球の溶血の熱的閾値] med./bio.

Thermal haemolytic threshold of human erythrocytes.

掲載誌: J Microw Power Electromagn Energy 1985; 20 (3): 161-163

この研究は、特別に設計されたマイクロ波装置を用いて、熱によるヒト赤血球溶血閾値を測定した。ヒトの全血サンプルおよび緩衝生理食塩水に赤血球を懸濁させたサンプルを用いて、第1実験(温度上昇中、断続ばく露。例えば、平均SAR = 250 mW/ gの場合、全血サンプルの最大温度は50 ℃)、および第2実験(温度一定の状態で断続ばく露を30分間。例えば、平均SAR = 250 mW/ gの場合、全血サンプルの最大温度は50 ℃)を実施した。その結果、全血中の赤血球の最初の溶血を引き起こすためには、50〜55 ℃の温度が必要であった;一方、緩衝生理食塩水に懸濁した赤血球溶血閾値は37℃に下がった;吸収エネルギー測定値に基づけば、溶血効果は本質的に熱的であるという結論を導くことができる、と報告している。

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研究目的(著者による)

To perform a systematic study of the thermal threshold for human blood.

詳細情報

Microwave heating is used in therapeutic treatment of several diseases. It is therefore useful to know the thermostability of red blood cells.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
ばく露時間: intermittent* during the growth phase
  • SAR: 250 mW/g mean (cf. remarks) (when the blood samples were heated upto 50°C)
ばく露2:
ばく露時間: intermittent* during the steady state temperature phase for at least 30 min
  • SAR: 250 W/kg mean (cf. remarks) (when the blood samples were heated up to 50°C)

General information

*Heating of samples were divided into 2 phases: Growth phase in which irradiation is applied when the temperature is below a given function in time. Steady state temperature in which irradiation is applied when the temperature falls below the preset value

ばく露1

主たる特性
ばく露時間 intermittent* during the growth phase
Additional information Microwave irradiation Reference article: Bacci M, Bini M, Checcucci A, Ignesti A, Millanta L, Rubino N and Vanni R (1981) J. Chem. Soc. Faraday Trans. 77: 1503-1509.
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源/構造
  • S-band waveguide
ばく露装置の詳細 The heating system consisted of a resonant cavity with sample positioned at the point of maximum coupling to the electric field.
Additional information The sample was contained in a Plexiglas cuvette (10 x 10 x 45 mm³) which was inserted in a section of an S-band waveguide filled with lossless thermal insulating material.
パラメータ
測定量 種別 Method Mass 備考
SAR 250 mW/g mean 電力損失による決定値 cf. remarks when the blood samples were heated upto 50°C

ばく露2

主たる特性
ばく露時間 intermittent* during the steady state temperature phase for at least 30 min
Additional information Microwave irradiation
Modulation
Modulation type unspecified
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
SAR 250 W/kg mean 電力損失による決定値 cf. remarks when the blood samples were heated up to 50°C

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Temperatures between 50 and 55°C are necessary to produce an initial haemolysis of red blood cells in the whole blood, while the thermal threshold drops to 37°C for erythrocytes suspended in buffered saline.

研究の種別:

研究助成

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