研究のタイプ: 医学/生物学の研究 (experimental study)

[13.56MHzの無線エネルギーへの長時間ばく露後のAS-1赤血球および全血由来血小板に対する急性の有害なイン・ビトロ影響は見られず] med./bio.

Absence of acute adverse in-vitro effects on AS-1 RBCs and whole blood-derived platelets following prolonged exposure to 13.56 MHz radio energy.

掲載誌: Transfusion 2010; 50 (7) Pt 2: 1596-1603

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研究目的(著者による)

To study the temperature and biological effects of 13.56 MHz radiofrequency exposure on red blood cells and whole blood-derived platelets under extreme exposure conditions.

詳細情報

There is growing interest in radio frequency identification (RFID) technology application for tracking blood products to achieve higher productivity and safety in the transfusion medicine supply chain.
A FDA-approved protocol with specific criteria concerning e.g. hemolysis or pH value was used.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 13.56 MHz
ばく露時間: continuous for 7 h or 23 -25 h

ばく露1

主たる特性
周波数 13.56 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 7 h or 23 -25 h
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 samples placed in the center of a 86 cm Helmholtz coil; magnetic field uniform within 1% in the exposure area; coil placed in a chamber made of Plexiglas laminates; positioned on a non-metallic, perforated test platform; exposure unit placed in a Faraday cage: Red blood cell products were tested in a walk-in refrigerator at a constant temperature of 1 - 6° C; whole blood-derived platelets products were tested in a temperature-controlled room at 20 - 24 °C
パラメータ
測定量 種別 Method Mass 備考
磁界強度 5 A/m - - - -
磁束密度 6.28 µT - - - -
電力 100 W - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

Hemolysis after 23-25 hours of very high radiofrequency energy exposure was 0.09% and 0.05%, respectively, for exposure and control red blood cell units and well within the ≤ 1% limit in the FDA-approved acceptance criteria.
For platelet units, the mean pH of exposure and control units was 7.27 and 7.19, respectively, following 23-25 hours of radiofrequency exposure, and well above the ≥ 6.2 acceptance limit value.
Furthermore, there was no detectable acceleration in cellular degradation of red blood cells and whole blood cell derived platelet products. While there was minimal temperature rise, the relative temperature increase between exposure and control units never exceeded the 1.5°C acceptance criterion.
In conclusion, 13.56 MHz-based RFID technology is unlikely to have any significant temperature or biological effects on red blood cells and whole blood cell derived platelet units under the normal operating conditions (a maximum of 4 W radiofrequency exposure for about 20 nonconsecutive minutes for RFID tracking during the life of the blood product).

研究の種別:

研究助成

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