この研究は、エコー平面磁気共鳴分光イメージング（EP-MRSI）と呼ばれる新しいタイプの磁気共鳴イメージング（MRI）の低エネルギー成分による低磁界磁気刺激（LFMS）が、抗うつ薬的効果、運動刺激効果、または健忘効果を持つか否かをラット実験で調べた。LFMSの効果の判定は、強制水泳試験（FST）での無動状態（水槽に投げ込まれたラットはやがて鼻だけ出して無動になる。この状態は抑うつ様状態とされる）、オープンフィールド試験における活動性を用いた。FSTセッション後にLFMS（1.5 G / cmおよび0.75 V / mでの20分間セッション3回）を受けさせた後に行動試験を実施した。また、ストレスばく露も含む学習パラダイムである恐怖条件付け（FC）に対するLFMSの影響も調べた。その結果、LFMSはFSTにおける無動を低下させた（すなわち、標準的な抗うつ薬と質的に類似した抗うつ薬様効果を示した）；LFMSは、運動活動性またはFCを変化させなかった、と報告している。
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To study whether a low-energy component of echo planar magnetic resonance spectroscopic imaging (low-field magnetic stimulation) has antidepressant-like, locomotor-stimulating, or amnestic effects in rats. The forced swim test was used.
The forced swim test is an animal model often used in the study of depression. It is a 2-day helplessness procedure in which rats swim under conditions in which escape is not possible.
Additionally, the effects on activity in an open field were examined to ensure that the effects that were observed in the forced swim test were not due to nonspecific effects on locomotion.
Rats were also used to confirm the efficacy of systemic doses of the standard antidepressant drugs fluoxetine or desipramine in the forced swim test.
Following treatments were used: LFMS (low field magnetic stimulation) within the focal point of the field, LFMS outside the focal point (10% LFMS), no field, constant DC, fluoxetine (20 mg/kg, IP) and desipramine (10 mg/kg, IP).
| 周波数 | 1 kHz |
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| タイプ |
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| 波形 |
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| ばく露時間 | 20 min |
| Modulation type | cf. additional information |
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| Additional information |
Low field magnetic stimulation (LMFS) consisting of 512 alternating trapezoids of 1 ms each. Electric field consisting of 512 square electric pulses of 0.25 ms each. |
| ばく露の発生源／構造 |
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| チャンバの詳細 | exposure cylinder/35.56 cm in diameter x 45.72 cm long x 1.59 cm think |
| ばく露装置の詳細 | 1h, 19 h or 23 h after forced swimming session, the rats were restrained individually in a plastic tube which was placed in the exposure cylinder. At 24 hours after the forced swim, rats were retested for 5 min under identical conditions. |
| 周波数 |
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| タイプ |
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| ばく露時間 | 20 min |
| Additional information | direct current magnetic field |
| ばく露の発生源／構造 |
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No parameters are specified for this exposure.
Low-field magnetic stimulation reduced immobility in the forced swim test, an antidepressant-like effect similar to that of standard antidepressants. Low-field magnetic stimulation did not alter locomotor activity or fear conditioning.
In conclusion, low-field magnetic stimulation has antidepressant-like effects in rats that seem unrelated to locomotor-activating or amnestic effects. These data raise the possibility that electromagnetic fields can affect the brain biology and might have physiologic consequences that offer novel approaches to therapy for psychiatric disorders.
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