研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットにおける低エネルギー磁界による頭蓋刺激の抗抑制様効果] med./bio.

Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats.

掲載誌: Biol Psychiatry 2005; 57 (6): 571-576

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研究目的(著者による)

To study whether a low-energy component of echo planar magnetic resonance spectroscopic imaging (low-field magnetic stimulation) has antidepressant-like, locomotor-stimulating, or amnestic effects in rats. The forced swim test was used.

詳細情報

The forced swim test is an animal model often used in the study of depression. It is a 2-day helplessness procedure in which rats swim under conditions in which escape is not possible.
Additionally, the effects on activity in an open field were examined to ensure that the effects that were observed in the forced swim test were not due to nonspecific effects on locomotion.
Rats were also used to confirm the efficacy of systemic doses of the standard antidepressant drugs fluoxetine or desipramine in the forced swim test.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1 kHz
ばく露時間: 20 min
ばく露2:
  • DC/static
ばく露時間: 20 min
-

General information

Following treatments were used: LFMS (low field magnetic stimulation) within the focal point of the field, LFMS outside the focal point (10% LFMS), no field, constant DC, fluoxetine (20 mg/kg, IP) and desipramine (10 mg/kg, IP).

ばく露1

主たる特性
周波数 1 kHz
タイプ
  • magnetic field
波形
  • sawtooth-shaped
ばく露時間 20 min
Modulation
Modulation type cf. additional information
Additional information

Low field magnetic stimulation (LMFS) consisting of 512 alternating trapezoids of 1 ms each. Electric field consisting of 512 square electric pulses of 0.25 ms each.

ばく露装置
ばく露の発生源/構造
  • head gradient coil comprising of a cylinder with three embedded magnetic coils
チャンバの詳細 exposure cylinder/35.56 cm in diameter x 45.72 cm long x 1.59 cm think
ばく露装置の詳細 1h, 19 h or 23 h after forced swimming session, the rats were restrained individually in a plastic tube which was placed in the exposure cylinder. At 24 hours after the forced swim, rats were retested for 5 min under identical conditions.
パラメータ
測定量 種別 Method Mass 備考
磁束密度 600 µT peak 指定なし - in the head at 4 cm; gradient magnetic field of 150 µT/cm
電界強度 7.5 mV/cm peak 計算値 - -

ばく露2

主たる特性
周波数
  • DC/static
タイプ
  • magnetic field
ばく露時間 20 min
Additional information direct current magnetic field
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ

No parameters are specified for this exposure.

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露前
  • ばく露後

研究の主なアウトカム(著者による)

Low-field magnetic stimulation reduced immobility in the forced swim test, an antidepressant-like effect similar to that of standard antidepressants. Low-field magnetic stimulation did not alter locomotor activity or fear conditioning.
In conclusion, low-field magnetic stimulation has antidepressant-like effects in rats that seem unrelated to locomotor-activating or amnestic effects. These data raise the possibility that electromagnetic fields can affect the brain biology and might have physiologic consequences that offer novel approaches to therapy for psychiatric disorders.

研究の種別:

研究助成

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