この研究は、健康なマウスおよび担がんマウス（TBM）のマクロファージおよびTリンパ球における腫瘍壊死因子（TNF）産生に対する弱いマイクロ波（MW）（8.15-18 GHz、1 µW/ cm2、1日1.5時間）の反復ばく露および酸化防止剤（AO）（β-カロチン、a-トコフェロール、ユビキノンQ 9）の摂取の影響を調べた。また、TBMの腫瘍サイズおよび死亡率も追跡調査した。その結果、MWばく露およびAO食餌は、健康なマウスの細胞におけるTNF産生を刺激した；初期段階では、腫瘍成長がマウス細胞のTNF産生を引き起こしたが、この効果は腫瘍成長とともに低下した；MWばく露を受けたTBMでは、TNF産生が無ばく露TBMよりも高かった；反対に、AO食餌は、健康なマウスのTNF産生を誘発したが、TBMでのTNF分泌には影響しなかった；したがって、TBMのMW長期処置（ただしAO食餌処置は無しでの）は腫瘍成長速度を低下させ、全体的に見た動物の寿命を延ばした、と報告している。
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To study the effects of repeated treatment with weak microwaves and diet with antioxidants (beta-carotene, alpha-tocopherol, and ubiquinone Q 9) on production of tumor necrosis factor in macrophages and T lymphocytes of healthy and tumor-bearing mice.
Feeding and microwave exposure were started on day 1 after transplantation of cancer cells. The animal cancer model was produced by subcutaneous injection of 2 x 105 Ehrlich ascites carcinoma cells in one hind limb. The mice were killed by decapitation of days 7, 14, and 30 after transplantation of cancer cells.
|Additional information||The frequency stability was better than 5%, and spectral width was better than 1 MHz. Higher harmonics were less than 25 dB.|
|Modulation type||cf. additional information|
Sweep frequency between 8.15 and 18 GHz with 1 s direct sweep time and 16 ms of reversed time
|Distance between exposed object and exposure source||80 cm|
|ばく露装置の詳細||animals kept in 25 cm x 25 cm x 45 cm plastic cages|
|Sham exposure||A sham exposure was conducted.|
Microwave exposure and antioxidant diet stimulated production of tumor necrosis factor in cells from healthy animals. At early stages, tumor growth induced tumor necrosis factor production in cells; however, this effect decreased as tumors grew. In tumor-bearing mice exposed to microwaves, tumor necrosis factor production was higher than in unexposed tumor-bearing animals.
Oppositely, antioxidant diet induced tumor necrosis factor production in healthy animals but did not affect tumor necrosis factor secretion in tumor-bearing mice. Accordingly, prolonged treatment of tumor-bearing mice to microwaves, but not to antioxidant diet, decreased tumor growth rate and increased overall animal longevity.
These data suggest that diminished tumor growth rate due to extremely low-level microwave exposure of mice carrying tumors, at least in part, was caused by enhancement in tumor necrosis factor production and accumulation of plasma tumor necrosis factor.