この研究は、マウスの腫瘍壊死因子（ＴＮＦ）産生および免疫応答に対するマイクロ波ばく露の影響を調べた。ばく露に用いたマイクロ波は、周波数8.15-18 GHz (1 Hz以内)、電力密度1μW/ cm2で、5時間の全身ばく露を1回実施した。その結果、ばく露により、腹腔マクロファージおよび脾臓T細胞でのTNF産生が有意に増加した；ばく露後に、Tリンパ球での分裂促進反応が増加した；細胞性免疫の活性化はばく露後3日以内に観察された；脂溶性栄養素（ベータカロチン、アルファトコフェロール、ユビキノンQ9）を含む食餌を与えると、ばく露マウスのマクロファージおよびT細胞の活性が上昇した、と報告している。
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To study the effect of weak 8.15-18 GHz microwaves on the tumor necrosis factor secretion and immune response. The aim of the study was to elucidate whether there is a synergism of the immunostimulating effects of low-intensity microwaves and antioxidants (beta-carotene, alpha-tocopherol, and ubiquinone Q9 were given daily with food prior to microwave exposure).
ばく露時間: continuous for 5 h
All details on irradiation described in the reference article
|ばく露時間||continuous for 5 h|
|Additional information||Animals (n=100) were divided in the following manner: n=40 control-cage mice, n=40 antioxidants-fed mice, n=20 sham exposed mice. Half of control-cage and antioxidants-fed groups were exposed to microwave irradiation.|
|Sham exposure||A sham exposure was conducted.|
A single 5 h exposure induced a significant increase in tumor necrosis factor production in peritoneal macrophages and splenic T cells. The mitogenic response in T lymphocytes increased after microwave exposure. The activation of cellular immunity was revealed within 3 days after irradiation. The diet containing antioxidant nutrients increased the activity of macrophages and T cells from exposed animals.
These data demonstrate that irradiation with low-power density microwaves stimulates the immune potential of macrophages and T cells. The antioxidant treatment enhances the effect of microwaves, in particular at later terms, when the effect of irradiation is reduced.