研究のタイプ: 医学/生物学の研究 (experimental study)

[マイクロ波と細胞性免疫:その2 マイクロ波と抗酸代謝の免疫刺激効果] med./bio.

Microwaves and cellular immunity. II. Immunostimulating effects of microwaves and naturally occurring antioxidant nutrients.

掲載誌: Bioelectrochem Bioenerg 1999; 49 (1): 37-41

この研究は、マウスの腫瘍壊死因子(TNF)産生および免疫応答に対するマイクロ波ばく露の影響を調べた。ばく露に用いたマイクロ波は、周波数8.15-18 GHz (1 Hz以内)、電力密度1μW/ cm2で、5時間の全身ばく露を1回実施した。その結果、ばく露により、腹腔マクロファージおよび脾臓T細胞でのTNF産生が有意に増加した;ばく露後に、Tリンパ球での分裂促進反応が増加した;細胞性免疫の活性化はばく露後3日以内に観察された;脂溶性栄養素(ベータカロチン、アルファトコフェロールユビキノンQ9)を含む食餌を与えると、ばく露マウスのマクロファージおよびT細胞の活性が上昇した、と報告している。

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的(著者による)

To study the effect of weak 8.15-18 GHz microwaves on the tumor necrosis factor secretion and immune response. The aim of the study was to elucidate whether there is a synergism of the immunostimulating effects of low-intensity microwaves and antioxidants (beta-carotene, alpha-tocopherol, and ubiquinone Q9 were given daily with food prior to microwave exposure).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 8.15–18 GHz
ばく露時間: continuous for 5 h

General information

All details on irradiation described in the reference article

ばく露1

主たる特性
周波数 8.15–18 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 5 h
Additional information Animals (n=100) were divided in the following manner: n=40 control-cage mice, n=40 antioxidants-fed mice, n=20 sham exposed mice. Half of control-cage and antioxidants-fed groups were exposed to microwave irradiation.
ばく露装置
ばく露の発生源/構造
  • 詳細不明
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 1 µW/cm² - - - -

Reference articles

  • Fesenko EE et al. (1999): [マイクロ波と細胞性免疫:その1 マウス細胞のでTNF産出に対する全身マイクロ波放射の影響]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

A single 5 h exposure induced a significant increase in tumor necrosis factor production in peritoneal macrophages and splenic T cells. The mitogenic response in T lymphocytes increased after microwave exposure. The activation of cellular immunity was revealed within 3 days after irradiation. The diet containing antioxidant nutrients increased the activity of macrophages and T cells from exposed animals.
These data demonstrate that irradiation with low-power density microwaves stimulates the immune potential of macrophages and T cells. The antioxidant treatment enhances the effect of microwaves, in particular at later terms, when the effect of irradiation is reduced.

研究の種別:

研究助成

関連論文