研究のタイプ: 医学／生物学の研究 (experimental study)

[アトピー性皮膚炎患者への携帯電話様ＲＦばく露の影響なし] med./bio.

No effect of mobile phone-like RF exposure on patients with atopic dermatitis

著者: Johansson A, Forsgren S, Stenberg B, Wilen J, Kalezic N, Sandström M
掲載誌: Bioelectromagnetics 2008; 29 (5): 353-362
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【目的】アトピー性皮膚炎（AD）の患者に対する携帯電話様RF電磁界ばく露の影響を調べること。【方法】AD群15人、およびマッチさせた対照群（非AD）15人の被験者を集めた。900MHzGSM携帯電話機に取り付けた屋内用基地局アンテナを介して、被験者を1W/kgでRF電磁界に30分間ばく露させた。血清中のサブスタンスP（SP）、腫瘍壊死因子（TNFR1）、脳由来神経栄養因子（BDNF）の濃度をELISA分析するための血液試料を誘発実験（ばく露／疑似ばく露）前後に採集した。ベースラインの心拍数、心拍数変動性、局所血流量、皮膚電位も記録された。【結果】ベースラインの神経生理学的データには両群の間に大きな差異は見られなかった。ベースラインにおいて、AD群の血清中TNFR1濃度は対照群より顕著に高く、BDNF濃度は顕著に低かった。SPは両群で違いがなかった。RFばく露条件に関連した影響は、測定したどの物質についても見られなかった。症状に関しては、報告数が非常に少なかったため、ばく露との相関の可能性は評価できなかった。【結論】アトピー性皮膚炎の患者におけるSP、TNFR1、BDNFの血清レベルへの携帯電話様RFばく露の影響の仮説は支持されなかった。

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研究目的（著者による）

This study investigated the effect of exposure to a mobile phone like radiofrequency electromagnetic field on people with atopic dermatitis.

詳細情報

Fifteen subjects (7 female, 8 male; mean age 31 years) with atopic dermatitis were recruited and matched with 15 controls without atopic dermatitis. Each subject was both sham exposed and electromagnetic field exposed.
Atopic dermatitis is a disease of the skin, characterized by strong pruritus and dry skin, often associated with other diseases like allergic rhinitis, asthma, food allergy.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 890 MHz
Modulation type: pulsed
ばく露時間: continuous for 30 min
  • SAR: 1 W/kg average over mass (1 g)

General information

The experiments were performed for approx. 6 months with a 3-month break during the pollen season.

ばく露1

主たる特性
周波数 890 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 30 min
Modulation
Modulation type pulsed
Pulse width 0.577 ms
Repetition frequency 217 Hz
Additional information

The DTX function was turned off.
ばく露装置
ばく露の発生源／構造
  • セルラ－電話
  • in test mode, with DC power supply, indoor base station antennas
Distance between exposed object and exposure source 8.5 cm
チャンバの詳細 The experiments were performed in an exposure chamber with negligible background levels of both power frequency and RF fields. The subjects were seated in a semi-reclining chair in front of an LCD computer screen on which a film was shown.
ばく露装置の詳細 Two antennas mounted on an adjustable wooden framework were placed at a distance of 8.5 cm, one on each side of the subject's head positioned between two wooden bars. The RF signal was directed via a power divider to a power meter and via a remotely controlled selector to the (left or) right antenna or a dummy load. RF exposure was applied from the right side only.
Sham exposure A sham exposure was conducted.
Additional information Each subject attended two sessions, a week apart, with real or sham exposure in random order. The exposure condition was not known by the experimenter or the subjects. However, the physiological recordings were distorted by the RF signal, so it was not possible to keep the study completely double blind.
パラメータ
測定量 値 種別 Method Mass 備考
SAR 1 W/kg average over mass 測定値 1 g -
Additional parameter details

The exposure setup [Wilen et al., 2006] was adjusted to give a rather homogenous SAR distribution in the parietal area of the head.

測定および計算の詳細

The SAR distribution was measured using a DASY3 system [Wilen et al., 2006].

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

No statistically significant effects of the radiofrequency exposure were found in any of the measured serum substances. Concerning mobile phone related symptoms a statistical evaluation could not be realized.

研究の種別:

研究助成

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