研究のタイプ: 医学/生物学の研究 (experimental study)

[マイクロ波にばく露したWistarラットの白血球における基礎的DNA損傷及び酸化ストレスの評価] retracted

RETRACTED: Evaluation of basal DNA damage and oxidative stress in Wistar rat leukocytes after exposure to microwave radiation.

掲載誌: Toxicology 2009; 259 (3): 107-112

この論文は、マイクロ波が引き起こすDNA損傷が基礎的なものか、あるいは活性酸素種により生じるものかを評価するために、Wistar系ラットに915MHzのマイクロ波ばく露を行った後、末梢血の白血球におけるDNAの変化を調べた。ばく露は、電力密度2.4W/m2のマイクロ波照射を1日1時間で2週間、全身SARは0.6 W/kg。結果として、インビボでの長期的ばく露により、基礎的損傷酸化損傷の両方が見られたと報告している。

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研究目的(著者による)

To study the effects of microwave exposure on DNA damage in rats and to assess whether microwave-induced DNA damage is basal or whether it is also generated through reactive oxygen species formation.

詳細情報

Eight rats were exposed and eight rats were sham-exposed. A modified comet assay was used to increase the sensitivity and to detect oxidative DNA damage.
This article has been retracted at the request of the Editors-in-Chief (further details).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 915 MHz
Modulation type: pulsed
ばく露時間: continuous for 1 h/day, 7 days/week for 2 weeks

ばく露1

主たる特性
周波数 915 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 1 h/day, 7 days/week for 2 weeks
Modulation
Modulation type pulsed
Additional information

basic GSM modulation

ばく露装置
ばく露の発生源/構造
  • GTEMセル
ばく露装置の詳細 animals placed in individual 25 cm x 7.5 cm x 7.5 cm Plexiglas cages inside the GTEM cell
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 2.4 W/m² - - - -
電界強度 30 V/m - - - uniform over the animal's body
SAR 0.6 W/kg average over mass - whole body -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Both the standard and the Fpg-modified comet assay detected increased DNA damage in blood leukocytes of the exposed rats. The significant increase in the Fpg-detected DNA damage suggests that oxidative stress is likely to be responsible. DNA damage detected by the standard comet assay indicates that some other mechanisms may also be involved.

研究の種別:

研究助成