研究のタイプ: 医学/生物学の研究 (experimental study)

[マウスの脳の海馬におけるカルシウム結合タンパク質に対する835 MHz高周波放射へのばく露の影響] med./bio.

Effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain.

掲載誌: Brain Res 2010; 1313: 232-241

この実験研究は、EMFばく露がカルビンジンD28-k(CB)やカルレチニン(CR)のようなカルシウム結合タンパク質(CaBP)の発現を変化させるか否かをマウスで実験した。835MHz のEMFへのばく露時間とSARは、毎日1時間×5日(比吸収率SAR)=1.6W/Kg)、毎日1時間×5日(SAR=4.0W/Kg)、 5時間×1日(SAR=1.6W/Kg)、 5時間×1日(SAR=4.0W/Kg)、終日×1ヶ月(SAR=1.6W/Kg)として、各条件でのばく露後に海馬免疫組織化学的に測定し、CBとCRの発現を調べた。その結果、CBとCRの免疫活性に見られた変化を報告している。

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研究目的(著者による)

To study whether radiofrequency exposure at 835 MHz (CDMA) affected changes in the expression of calcium binding proteins like calbindin-D(28k) and calretinin in the mouse hippocampus at SAR values of 1.6 W/kg and 4 W/kg at different exposure durations.

詳細情報

Radiofrequency exposure might alter intracellular signaling pathways through changes in calcium permeability across cell membranes. Changes in the expression of calcium binding proteins could indicate impaired Ca2+ homeostasis.
60 mice were divided into six groups (each n=10): 1) control group, 2) 1.6 W/kg exposure group (1 h, 5 days), 3) 4 W/kg exposure group (1 h, 5 days), 4) 1.6 W/kg exposure group (5 h, 1 day), 5) 4 W/kg exposure group (5 h, 1 day), 6) one month exposure group. Animals were sacrificed three hours following the terminal exposure.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 835 MHz
ばく露時間: continuous exposure for up to one month (see details)
  • SAR: 4 W/kg average over mass (whole body) (exposure group high energy)
  • SAR: 1.6 W/kg average over mass (whole body) (exposure group low energy)

ばく露1

主たる特性
周波数 835 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous exposure for up to one month (see details)
Modulation
Modulation type cf. additional information
Additional information

CDMA

ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 exposure device: Wave Exposer V20
Additional information 6 exposure groups with 10 mice each: A) control B) 1 h daily at low energy for 5 days C) 1 h daily at high energy for 5 days D) 5 h at low energy for 1 day E) 5 h at high energy for 1 day F) 1 month at low energy
パラメータ
測定量 種別 Method Mass 備考
SAR 4 W/kg average over mass 測定値および計算値 whole body exposure group high energy
SAR 1.6 W/kg average over mass 測定値および計算値 whole body exposure group low energy

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露前
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The body weights of the different groups did not change significantly. The data showed an almost complete pyramidal cell loss in the hippocampal CA1 area of mice exposed to electromagnetic fields for one month (group 6). The authors conclude that 835 MHz radiofrequency exposure may be harmful.

研究の種別:

研究助成

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