目的と方法 ：低レベルの超高周波電磁界（42.2 GHz、0.1 mW/cm2 、ばく露時間20分）の影響を、正常マウスおよび腹膜の炎症があるマウスの胸腺細胞および血漿の脂肪酸組成について調べた。結果 ：正常マウスへのばく露により、胸腺細胞の多価不飽和脂肪酸（PUFA）（エイコサペンタエン酸およびドコサペンタエン酸）の濃度上昇が見られた。ザイモサン誘発性腹膜炎症のモデルマウスを用いた場合、ばく露により胸腺細胞のPUFA（ジホモ－g－リノレン酸、アラキドン酸、エイコサペンタエン酸、ドコサペンタエン酸、ドコサペンタヘキ酸）の有意な濃度上昇、および一価不飽和脂肪酸（MUFA）（パルミトオレイン酸、オレイン酸）の濃度低下を示した。血漿中の脂肪酸組成変化は明白でなく、炎症時の飽和脂肪酸レベル上昇が見られた。結論 ：我々のデータは、PUFAが外部から胸腺細胞に入ることによりMUFAに置き換わるという考えを支持する。PUFAの代謝物質は炎症や免疫の反応に関係が深い脂質メッセンジャーであることを考慮して、我々は、細胞膜のリン脂質におけるPUFA濃度上昇が超高周波電磁界の抗炎症作用の実現を促進すると想定する。
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To study the effects of low-intensity extremely high frequency electromagnetic radiation (42.2 GHz) on the fatty acid composition of thymic cells and blood plasma in normal mice and in mice with peritoneal inflammation.
Inflammation was induced by intraperitoneal zymosan injection. Four groups of mice (each group n=2) were used: (1) sham exposure group (injected with physiological saline solution); (2) exposure group (injected with saline solution); (3) sham exposure group (with zymosan-induced peritoneal inflammation); (4) exposure group (with zymosan-induced peritoneal inflammation). The experiments were repeated three times. At 4 h after exposure/sham exposure the mice were decapitated.
Mice were divided into four groups: i) sham exposure ii) RF exposure iii) induced inflammation + sham exposure iv) induced inflammation + RF exposure
| 周波数 | 42.2 GHz |
|---|---|
| タイプ |
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| 特性 |
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| ばく露時間 | continuous for 20 min |
| Modulation type | CW |
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| ばく露の発生源／構造 | |
|---|---|
| Distance between exposed object and exposure source | 300 mm |
| ばく露装置の詳細 | animals kept in a 100 mm x 100 mm x 130 mm plastic container; multilayer absorbent placed between the animal container and the floor; antenna's major lobe width = 130 mm at 300 mm distance; exposure from the top |
| Sham exposure | A sham exposure was conducted. |
The data showed that the exposure of normal mice to low-intensity extremely high frequency electromagnetic radiation significantly increased the content of polyunsaturated fatty acids (eicosapentaenoic acid and docosapentaenoic acid) in thymic cells. Using the inflammation model, it was shown that the exposure of mice significantly increased the content of polyunsaturated fatty acids (dihomo-gamma-linolenic acid, arachidonic acid, eicosapentaenoic, docosapentaenoic, and docosahexaenoic) and reduced the content of monounsaturated fatty acids (palmitoleic acid and oleic acid) in thymic cells.
Changes in the fatty acid composition in the blood plasma were less pronounced and became manifest in an increase in the level of saturated fatty acids during the inflammation.
The authors conclude that the changes of fatty acid composition induced by low-intensity extremely high frequency electromagnetic radiation may be considered as a key element in the mechanisms of biological effects of radiation.
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