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To investigate the effects of zinc supplementation on the oxidative damage in lung and liver tissues of rats exposed to an extremely low frequency magnetic field.
Three groups of rats were examined (n=8 per group): 1.) control group, 2.) magnetic field exposure and 3.) magnetic field exposure + daily zinc supplementation (injection of 3 mg zinc per kg body weight for 6 month).
|ばく露時間||continuous for 5 min every other day during 6 months|
|ばく露装置の詳細||rats kept in 35 cm x 25 cm x 25 cm polyvinyl chloride cages with a single turn of 0.3 mm diameter copper wire wound around them for generation of the magnetic field; mean temperature 22°C; relative humidity 55% to 60%|
|Sham exposure||A sham exposure was conducted.|
In the exposure group, the lipid peroxidation in the lung and liver was significantly increased compared to the control group. A supplementation of zinc significantly lowered the lipid peroxidation compared to the exposure group without zinc, but the level of lipid peroxidation remained significantly higher in comparison to the control group.
The level of glutathione was significantly increased in the lung and liver of exposed rats when compared to the control group. A further significant increase in the concentration of glutathione was observed in exposed rats with zinc supplementation when compared to the exposure group without zinc.
In the lung and liver tissues of exposed rats, the content of zinc was significantly decreased in comparison to the control group, while in the lung and liver tissues of exposed rats with zinc supplementation the zinc content was significantly increased.
The authors conclude that exposure of rats to extremely low frequency magnetic fields could induce tissue damages in the lung and liver and that zinc supplementation could attenuate these damages.