この研究は、50Hz電界にばく露したラットにおいて、事象関連電位（ERP）の成分であるミスマッチ陰性電位（MMN）反応を測定し、その後、脳組織のアポトーシスおよび酸化的損傷を測定した。90匹の3月齢ラットを15匹ずつの6群に分けた：2週間の擬似ばく露群（C2）、4週間の擬似ばく露群（C4）、2週間の電界（12 kV/mまたは18kV/m）ばく露群（E12-2、E18-2）、同じく4週間ばく露群（E12-4、E18-4）。ばく露終了後に麻酔下でMMNを測定した後、屠殺して組織検査を実施した。その結果、電界強度およびばく露時間に依存して、ERPパラメータが変化した；E18-4群ではC4群に比べ、MMN振幅が有意に低下した；全てのばく露群で対照群に比べ、4ヒドロキシノネナール量が増加していた、と報告している。
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To investigate the effect of exposure to a 50 Hz-electric field on mismatch negativity component of event-related potentials as well as on apoptosis and oxidative stress in the rat brain.
6 groups of rats were examined (n= 15 per group): 1.) sham exposure for 2 weeks, 2.) sham exposure for 4 weeks, 3.) exposure to an electric field, 12 kV/m for 2 weeks, 4.) exposure to an electric field, 18 kV/m for 2 weeks, 5.) exposure to an electric field, 12 kV/m for 4 weeks and 6.) exposure to an electric field, 18 kV/m for 4 weeks.
At the end of the exposure/sham exposure period mismatch negativity responses were recorded in anesthetized rats. Afterwards, rats were killed and brain tissues were removed.
| 周波数 | 50 Hz |
|---|---|
| タイプ |
|
| ばく露時間 | 1 hour/day for 2 or 4 weeks |
| ばく露の発生源／構造 |
|
|---|---|
| チャンバの詳細 | rats were exposed in plastic cages |
| ばく露装置の詳細 | parallel copper plates (50 x 80 cm) were plated with zinc (2-mm thickness); corners of parallel plates were rounded to produce an uniform electric field; plates were placed upright on wooden stands and positioned parallel to each other; plastic cage was placed between plates; plates were spaced at 50 cm distance |
| Sham exposure | A sham exposure was conducted. |
| Additional information | maximum background magnetic field was 0.1 µT (measured), homogeneity and uniformity of electric field was measured (maximum variation less than 1 %) |
In all exposure groups, the lipid peroxidation was significantly increased compared to the corresponding sham exposure groups. In comparison to the control group, the content of carbonyl groups was significantly increased in group 4 (18 kV/m for 2 weeks), group 5 (12 kV/m for 4 weeks) and group 6 (18 kV/m for 4 weeks). However, no apoptotic cells were found in any of the groups.
In group 6 (18 kV/m for 4 weeks), the mismatch negativity amplitude was significantly decreased in comparison to the 4 weeks sham exposure group. In group 3 (12 kV/m for 2 weeks) and group 4 (18 kV/m for 2 weeks), the mismatch negativity latency was significantly increased compared to the 2 weeks sham exposure group.
The authors conclude that exposure to a 50 Hz-electric field could have an influence on mismatch negativity component of event-related potentials in rats and that these effects could be due to oxidative stress in the rat's brain.
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