研究のタイプ: 医学/生物学の研究 (experimental study)

[ラットの脳のモノアミン神経伝達物質およびそれらの重要な制御酵素に対する低強度のマイクロ波放射の影響] med./bio.

Effect of Low-Intensity Microwave Radiation on Monoamine Neurotransmitters and Their Key Regulating Enzymes in Rat Brain.

掲載誌: Cell Biochem Biophys 2015; 73 (1): 93-100

この研究は、フィッシャ−ラットの脳のモノアミン神経伝達物質、それらを制御する重要な酵素遺伝子発現に対する低強度のマイクロ波放射の影響を調べた。マイクロ波(900MHzまたは1800MHz、SARは両方とも約0.6mW/kg)のばく露を30日間(1日2時間、週5日)行った。ばく露終了後に脳の海馬ドーパミン(DA)、ノルエピネフリン(NE)、エピネフリン(E)セロトニン(5-HT)のレベル、チロシン酸化酵素(TH)およびトリプトファン水酸化酵素(TPH1および2)のmRNA発現を測定した。その結果、対照(擬似ばく露)群に比べ、マイクロ波ばく露群では、海馬のDA、NE、E、5-HTレベルが有意に低下した;同じく、TH、TPH1および2のmRNA発現が有意に低下した、と報告している。

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研究目的(著者による)

To investigate the effects of exposure to low-intensity microwaves on monoamine neurotransmitter levels and their key regulating enzymes in the brain of rats.

詳細情報

Three groups of rats were examined (n=6 per group): 1.) sham exposure, 2.) 900 MHz microwave exposure and 3.) 1800 MHz microwave exposure.
The enzyme tyrosine hydroxylase catalyzes the reaction to form a precursor for dopamine, which, in turn, is a precursor for the neurotransmitters norepinephrine and epinephrine. Tryptophan hydroxylase is an enzyme involved in the synthesis of the neurotransmitter serotonin.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
ばく露時間: 2 hours per day, 5 days per week
ばく露2: 1,800 MHz
ばく露時間: 2 hours per day, 5 days per week

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 2 hours per day, 5 days per week
ばく露装置
ばく露の発生源/構造
  • GTEMセル
Distance between exposed object and exposure source 100 cm
チャンバの詳細 rats were restrained in closed boxes (L: 30 cm x B: 15 cm x H: 20 cm), provided with holes of 1 cm diameter for ventilation and were kept at a distance of 100 cm from the source
ばく露装置の詳細 GTEM cell was a pyramidal tapered, dual-terminated section (L: 220 cm x B: 120 cm x H: 80 cm); microwave source consisted of a signal generator operating at a frequency range of 9 kHz to 3.2 GHz, an amplifier, a DC regulator and a power meter; microwave chamber was lined with absorbers to minimize reflections
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
SAR 0.5953 mW/kg - 計算値 - -
電力 1 mW - - - -

ばく露2

主たる特性
周波数 1,800 MHz
タイプ
  • electromagnetic field
ばく露時間 2 hours per day, 5 days per week
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
パラメータ
測定量 種別 Method Mass 備考
SAR 0.5835 mW/kg - 計算値 - -
電力 1 mW - - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The levels of the neurotransmitters dopamine, norepinephrine, epinephrine were significantly decreased in exposed rats (900 MHz and 1800 MHz) compared to sham exposed rats. The level of serotonin was also decreased in the exposed groups when compared to the sham exposure, but only significantly in the group exposed to the 1800 MHz microwaves. Additionally, in both exposure groups the gene expression of the enzymes tyrosine hydroxylase and tryptophan hydroxylase was significantly decreased in comparison to the sham exposed animals.
The authors conclude that exposure to low-intensity microwaves influences monoamine neurotransmitter levels and their key regulating enzymes in the brain of rats.

研究の種別:

研究助成

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