研究のタイプ: 医学/生物学の研究 (experimental study)

[GSM900 MHz電磁界への急性ばく露はラット脳のグリア反応と生化学的な変化をもたらす] med./bio.

Acute exposure to GSM 900-MHz electromagnetic fields induces glial reactivity and biochemical modifications in the rat brain.

掲載誌: Neurobiol Dis 2004; 17 (3): 445-454

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研究目的(著者による)

To study the response of the rat brain to an acute exposure to high power GSM 900 MHz microwaves at multiple levels: biochemical effects on neurotransmitter receptors (NMDA (N-methyl-D-aspartate) and GABA (gamma aminobutyric acid)) and transporters (dopamine), and cellular (extent of glial reaction) and behavioral effects.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: pulsed
ばく露時間: continuous for 15 min
  • SAR: 6 W/kg average over mass (brain)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 15 min
Modulation
Modulation type pulsed
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
  • 無響室
  • loop antennas, microwave generator
ばく露装置の詳細 The exposure system has been described in the reference article. Rats were held in Plexiglas restrainers to avoid any movement of their heads. Individual loop antennas were fixed between two Plexiglas plates above their heads.
Additional information Sham and exposed rats were processed in parallel.
パラメータ
測定量 種別 Method Mass 備考
SAR 6 W/kg average over mass 測定値および計算値 brain -

Reference articles

  • Mausset AL et al. (2001): [ラット小脳のGABA作動系に対する無線周波ばく露の影響:半定量的免疫組織化学からの手がかり]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Acute exposure to high power GSM 900 MHz microwaves is able to induce 1) a strong glial immunoreactivity in different structures of the brain, 2) a significant reduction of the presence of NMDA receptors at the postsynaptic membrane level in the cortex and the striatum, and 3) biochemical modifications of neurotransmitter receptor properties. Although the authors showed that the rat general locomotor behavior was not significantly altered on the short term, the data provide the first evidence for rapid cellular and molecular alterations in the rat brain after an acute exposure to high power GSM 900 MHz microwaves.

研究の種別:

研究助成

Replication studies

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