この研究は、麻酔処置されたラットを用いて、パルス化2.8GHz電磁放射（RFR）に対する熱応答における中枢神経系刺激剤ドキサプラムの影響を調べた。その結果、平均電力密度60 mW / cm 2への断続的なばく露において、ばく露を中断した時に体温がばく露前のレベルに戻るのに要する時間が、ドキサプラム投与により有意に長くなった；致死温度になるまでばく露を続けた場合、ドキサプラム投与は、生理食塩水投与の対照と比較して、生存期間に有意な変化を生じさせなかった；以上から、この薬剤はRFRの断続的ばく露中の体温調節効率を低下させたが、致死的なRFRばく露に対する感受性の変化を起こさなかった、と報告している。
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To study the effects of the central nervous system stimulant, doxapram, on the thermal responses to 2.8 GHz pulsed radiofrequency radiation in anaesthetized rats.
The 2.8 GHz frequency is characteristic of high power stationary tracking radars for military applications. In view of previously reported hyperthermic effects of doxapram in rodents, it is possible that doxapram may act to reduce the hyperthermic response to radiofrequency radiation and may be of value in cases of accidental exposure at high power densities.
|ばく露時間||intermittent, about 7-10 min on/11-20 min off, for 2 x 3 cycles, see below|
|Pulse width||2 µs|
|Repetition frequency||500 Hz|
|ばく露装置の詳細||Anaesthetized animals were positioned on a Plexiglas holder and exposed in the H-orientation with their long axis parallel to the H-field.|
|Additional information||Animals were exposed until their colonic temperature rose to 39.5°C. Exposure was repeated when the temperature returned to 38.5°C. This procedure was repeated for three cycles. Then, at 38.5°C, either doxapram or saline was administered i.p. After a 15 min interval, exposure was resumed for another three (or four?) cycles. Finally, starting at 38.5°C, exposure was performed until a lethal temperature of 42.8 ± 0.2°C was attained after another 30-35 min.|
During intermittent exposure to an average power density of 60 mW/cm², doxapram significantly increased the time required for temperature to return to the pre-irradiation level. When irradiation was continued until death, doxapram administration caused no significant change in survival time when compared to saline controls. Thus, although the drug decreased thermoregulatory efficiency during intermittent radiofrequency exposure, no change in susceptibility to terminal radiofrequency exposure was observed. Although doxapram can cause hypothermia under certain conditions, the drug does not appear to be of value in cases of accidental radiofrequency exposure.