研究のタイプ: 医学/生物学の研究 (experimental study)

[無線周波放射中のラットの体温に対するドキサプラムの影響] med./bio.

Effects of doxapram on body temperature of the rat during radiofrequency irradiation.

掲載誌: Clin Exp Pharmacol Physiol 1985; 12 (1): 1-8

この研究は、麻酔処置されたラットを用いて、パルス化2.8GHz電磁放射(RFR)に対する熱応答における中枢神経系刺激ドキサプラムの影響を調べた。その結果、平均電力密度60 mW / cm 2への断続的なばく露において、ばく露を中断した時に体温がばく露前のレベルに戻るのに要する時間が、ドキサプラム投与により有意に長くなった;致死温度になるまでばく露を続けた場合、ドキサプラム投与は、生理食塩水投与の対照と比較して、生存期間に有意な変化を生じさせなかった;以上から、この薬剤はRFRの断続的ばく露中の体温調節効率を低下させたが、致死的なRFRばく露に対する感受性の変化を起こさなかった、と報告している。

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研究目的(著者による)

To study the effects of the central nervous system stimulant, doxapram, on the thermal responses to 2.8 GHz pulsed radiofrequency radiation in anaesthetized rats.

詳細情報

The 2.8 GHz frequency is characteristic of high power stationary tracking radars for military applications. In view of previously reported hyperthermic effects of doxapram in rodents, it is possible that doxapram may act to reduce the hyperthermic response to radiofrequency radiation and may be of value in cases of accidental exposure at high power densities.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.8 GHz
Modulation type: pulsed
ばく露時間: intermittent, about 7-10 min on/11-20 min off, for 2 x 3 cycles, see below

ばく露1

主たる特性
周波数 2.8 GHz
タイプ
  • electromagnetic field
ばく露時間 intermittent, about 7-10 min on/11-20 min off, for 2 x 3 cycles, see below
Modulation
Modulation type pulsed
Pulse width 2 µs
Repetition frequency 500 Hz
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 Anaesthetized animals were positioned on a Plexiglas holder and exposed in the H-orientation with their long axis parallel to the H-field.
Additional information Animals were exposed until their colonic temperature rose to 39.5°C. Exposure was repeated when the temperature returned to 38.5°C. This procedure was repeated for three cycles. Then, at 38.5°C, either doxapram or saline was administered i.p. After a 15 min interval, exposure was resumed for another three (or four?) cycles. Finally, starting at 38.5°C, exposure was performed until a lethal temperature of 42.8 ± 0.2°C was attained after another 30-35 min.
パラメータ
測定量 種別 Method Mass 備考
電力密度 60 mW/cm² mean 測定値 - -
SAR 14 W/kg mean 推定値 - [Durney et al., 1978]

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

During intermittent exposure to an average power density of 60 mW/cm², doxapram significantly increased the time required for temperature to return to the pre-irradiation level. When irradiation was continued until death, doxapram administration caused no significant change in survival time when compared to saline controls. Thus, although the drug decreased thermoregulatory efficiency during intermittent radiofrequency exposure, no change in susceptibility to terminal radiofrequency exposure was observed. Although doxapram can cause hypothermia under certain conditions, the drug does not appear to be of value in cases of accidental radiofrequency exposure.

研究の種別:

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