この研究は、薬理学的効果とマイクロ波ばく露の関連を、３つの実験により調べた。その結果、パルス化2.70 GHzマイクロ波は、20 mW/ cm2までの電力密度では、ペンチレンテトラゾールの発作誘発効果、またはその発作を抑制するクロルジアゼポキシドの効果に影響を与える証拠は得られなかった；マイクロ波ばく露は、クロルジアゼポキシドの発作抑制効果を変えることなく、同薬剤の低体温誘発効果を打ち消した；これは、マイクロ波による熱効果と薬理学的効果の間の解離を強調している、と報告している。
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To determine whether brief pulsed microwave exposures altered susceptibility to pentylenetetrazol (PTZ, induces seizures by blocking the inhibitory effect of GABA as well as by a direct effect on neuronal membranes) seizures or the efficacy of chlordiazepoxide (CDZ) for counteracting PTZ seizures.
|ばく露時間||continuous for 30 min|
|Pulse width||2 µs|
|Repetition frequency||500 Hz|
|Distance between exposed object and exposure source||110 cm|
|チャンバの詳細||The antenna was a multiridged rectangular horn with a diagonal aperture of 20.5 cm radiating vertically downward into an anechoic chamber of 1.7 m x 2.6 m x 2.6 m.|
|ばく露装置の詳細||Rats were placed in vented circular acrylic cages of 15.3 cm diameter and 9.5 cm height with 6 mm thick acrylic lids and floors.|
|Sham exposure||A sham exposure was conducted.|
|Additional information||Up to four rats could be exposed at a time at four positions of equal power density spaced about 3 λ apart. However, due to handling constraints, only two rats were exposed at a time.|
The experiments failed to provide consistent evidence for an effect of 2.70 GHz pulsed microwave exposure up to 20 mW/cm² on PTZ-induced seizures or on the efficacy of CDZ for counteracting such seizures. One consistent result across all experiments was that pulsed microwaves elevated core temperatures and this was proportional to the power density. Microwave exposure counteracted the hypothermic effects of CDZ without altering its anti-seizure efficacy. This underscores the dissociation between thermal and pharmacological effects of microwave exposure.