研究のタイプ: 医学/生物学の研究 (experimental study)

[2.45GHz放射のばく露を受けた発達中のラット脳細胞におけるプロテインキナーゼC活性] med./bio.

Protein kinase C activity in developing rat brain cells exposed to 2.45 GHz radiation.

掲載誌: Electromagn Biol Med 2006; 25 (1): 61-70

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研究目的(acc. to editor)

To study the effect of 2.45 GHz exposure on calcium-dependent protein kinase C (PKC) enzyme activity and morphological changes in the developing rat brain.

詳細情報

PKC was determined in the whole brain, hippocampus and whole brain minus hippocampus separately of six rats (35 days old). Morphological changes were investigated in additional six rats.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
Modulation type: pulsed
ばく露時間: continuous for 2 h/day on 35 days

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 2 h/day on 35 days
Modulation
Modulation type pulsed
Duty cycle 25 %
ばく露装置
ばく露の発生源/構造
ばく露装置の詳細 wooden anechoic chamber lined on the inside with pyramidal black radar absorbing material (40 dB); horn antenna positioned at one end of the chamber at a distance of 2 d²/λ from the cage; six rats placed individually in one of the six compartments (arranged in 2 columns and 3 rows) of a 43 cm x 27 cm x 15 cm Plexiglas cage inside the chamber; cage and chamber ventilated and temperature kept constant at 30°C; animals restraint during exposure
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力 1.2 mW - 測定値 - -
電力密度 0.344 mW/cm² - - - -
SAR 0.11 W/kg - 計算値 whole body -

Reference articles

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

The data revealed a statistically significant decrease in PKC enzyme activity in the hippocampus and the whole brain when compared with the rest of the brain (whole brain - hippocampus) and compared with the control group.
Additionally, glial cell population was increased in the exposed group as compared with the control group.
The authors conclude that chronic exposures may affect brain growth and brain development.

研究の種別:

研究助成

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