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To study the effect of 2.45 GHz exposure on calcium-dependent protein kinase C (PKC) enzyme activity and morphological changes in the developing rat brain.
PKC was determined in the whole brain, hippocampus and whole brain minus hippocampus separately of six rats (35 days old). Morphological changes were investigated in additional six rats.
|ばく露時間||continuous for 2 h/day on 35 days|
|Duty cycle||25 %|
|ばく露装置の詳細||wooden anechoic chamber lined on the inside with pyramidal black radar absorbing material (40 dB); horn antenna positioned at one end of the chamber at a distance of 2 d²/λ from the cage; six rats placed individually in one of the six compartments (arranged in 2 columns and 3 rows) of a 43 cm x 27 cm x 15 cm Plexiglas cage inside the chamber; cage and chamber ventilated and temperature kept constant at 30°C; animals restraint during exposure|
|Sham exposure||A sham exposure was conducted.|
The data revealed a statistically significant decrease in PKC enzyme activity in the hippocampus and the whole brain when compared with the rest of the brain (whole brain - hippocampus) and compared with the control group.
Additionally, glial cell population was increased in the exposed group as compared with the control group.
The authors conclude that chronic exposures may affect brain growth and brain development.