Study type: Medical/biological study (experimental study)

Cell type-specific genotoxic effects of intermittent extremely low-frequency electromagnetic fields. med./bio.

Published in: Mutat Res Genet Toxicol Environ Mutagen 2005; 583 (2): 184-188

Aim of study (acc. to author)

To study whether intermittent extremely low frequency electromagnetic fields exposure causes similar effects in cell types other than human fibroblasts.

Background/further details

Temperature was continuously monitored and temperature difference between the chambers did not exceed 0.3°C.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: intermittent, 5 min on/10 min off, for 1 to 24 h in 1 h steps

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration intermittent, 5 min on/10 min off, for 1 to 24 h in 1 h steps
Additional info vertical magnetic field
Exposure setup
Exposure source
Setup four coil systems, two coils with 56 windings and two coils with 50 windings; both coil systems were placed inside mu-metal boxes which were then placed in a commercial incubator (5% CO2, 37°C, 95% humidity)
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated material:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data show that the induction of DNA strand breaks by exposure to intermittent extremely low frequency electromagnetic fields is cell type-specific. The authors could identify three responder (human fibroblasts, human melanocytes, rat granulosa cells) and three non-responder cell types (human lymphocytes, human monocytes, human skeletal muscle cells), which points to the significance of the cell system used when investigating genotoxic effects.

Study character:

Study funded by

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