Study type: Medical/biological study (experimental study)

Effects of sinusoidal magnetic field observed on cell proliferation, ion concentration, and osmolarity in two human cancer cell lines. med./bio.

Published in: Electromagn Biol Med 2006; 25 (2): 113-126

Aim of study (acc. to author)

To study the effects of 50 Hz sinusoidal magnetic field (20 mT) on cell proliferation, ion concentration, and osmolarity in two human cancer cell lines.

Background/further details

The K+ channel plays an important role in the regulation of cell cycle progression, apoptosis, and immunoreactions involved in tumorigenesis. The Na+ ion is involved in a large number of physiological, biochemical, and morphological aspects of cell function.
The active transport of Na+ from the cell and K+ into the cell is connected to the osmotic stabilization of a living cell. Medium osmolarity has effects on cell function.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuously for 1, 2, 3 or 4 days

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Waveform
Exposure duration continuously for 1, 2, 3 or 4 days
Exposure setup
Exposure source
Setup vertical magnetic field; cells were placed in the center of the coils
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 20 mT unspecified measured - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure

Main outcome of study (acc. to author)

The data indicate that the 20 mT, 50 Hz magnetic field changed the cell proliferation, ion concentration and osmolarity of HL-60 and SK-HEP-1 cells. The increase in ion concentration and osmolarity corresponded to the decrease in cell density.
In addition, a theoretical model of cells exposed to the oscillating magnetic field is described as well as the characteristics of ions in and out of cells. The experimental data appeared to be consistent with the theoretical analysis. Magnetic field inhibitions of cell growth in vitro may relate to changes in cell ion concentration and osmolarity.

Study character:

Study funded by

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