Study type: Medical/biological study (experimental study)

Fifty hertz extremely low-frequency electromagnetic field causes changes in redox and differentiative status in neuroblastoma cells. med./bio.

Published in: Int J Biochem Cell Biol 2007; 39 (11): 2093-2106

Aim of study (acc. to author)

This study was performed to examine the effects of extremely low frequency electromagnetic fields on oxidative homeostasis in human neurons in vitro.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 50 Hz
Exposure duration: continuous up to 96 h; for in situ neurodifferentiation analysis 192 h

Exposure 1

Main characteristics
Frequency 50 Hz
Type
Exposure duration continuous up to 96 h; for in situ neurodifferentiation analysis 192 h
Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 1 mT - measured - +/- 2 %

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

After the exposure to extremely low frequency electromagnetic fields a positive effect on antioxidant enzymatic expression was observed, as well as a significant increase in reduced glutathione level.
The electromagnetic field exposure induced a more differentiated phenotype as well as an increased expression in the transcription factors related to neuronal differentiation and cellular stress response ("peroxisome proliferators-activated receptor isotype beta", PPARβ).
The tolerance towards the oxidative attack with H2O2 was reduced in cells exposed to electromagnetic fields.

Study character:

Study funded by

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