研究のタイプ: 医学/生物学の研究 (experimental study)

[雌雄のラットにおける血液脳関門の透過性に対する無線周波放射ばく露の影響] med./bio.

Effects of radiofrequency radiation exposure on blood-brain barrier permeability in male and female rats.

掲載誌: Electromagn Biol Med 2011; 30 (4): 253-260

この研究では、0.9及び1.8GHzの連続波(CW)無線周波放射への20分間のばく露(SARはそれぞれ4.26mW/kg及び1.46mW/kg)が、雌雄のWistarアルビノラット血液脳関門BBB)の透過性に及ぼす影響を調べた。その結果、ばく露群の雄ラットの脳で偽ばく露群の雄の脳と比較してアルブミン有意な増加が認められたことを報告している。

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研究目的(著者による)

To study the effect of radiofrequency exposure on the permeability of the blood-brain barrier in male and female rats.

詳細情報

The right hemisphere, left hemisphere, cerebellum, and total brain were analyzed separately.
The animals were divided into six groups (n=9 per proup): 1) sham exposed female rats, 2) sham exposed male rats, 3) 0.9 GHz exposed females 4) 0.9 GHz exposed males, 5) 1.8 GHz exposed females, 6) 1.8 GHz exposed males.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 0.9 GHz
Modulation type: CW
ばく露時間: continuous for 20 min
  • 電界強度: 4.71 V/m (± 0.02 V/m)
  • SAR: 4.26 mW/kg average over mass (10 g) (brain tissue)
ばく露2: 1.8 GHz
Modulation type: CW
ばく露時間: continuous for 20 min
  • 電界強度: 4.92 V/m (± 0.12 V/m)
  • SAR: 1.46 mW/kg average over mass (10 g) (brain tissue)

General information

The animals were treated in the following six groups: i) female sham exposure ii) male sham exposure iii) female exposure to 0.9 GHz iv) male exposure to 0.9 GHz v) female exposure to 1.8 GHz vi) male exposure to 1.8 GHz

ばく露1

主たる特性
周波数 0.9 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 20 min
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
Distance between exposed object and exposure source 10 cm
ばく露装置の詳細 rats were anesthetized during exposure; rats exposed individually with their body parallel to the E-field component of the RF-field
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 4.71 V/m - - - ± 0.02 V/m
SAR 4.26 mW/kg average over mass 計算値 10 g brain tissue

ばく露2

主たる特性
周波数 1.8 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 20 min
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • E1と同じ装置
Distance between exposed object and exposure source 10 cm
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電界強度 4.92 V/m - - - ± 0.12 V/m
SAR 1.46 mW/kg average over mass 計算値 10 g brain tissue

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

No albumin extravasation was found in the brains of female rats after radiofrequency exposure. However, a significant increase in albumin extravasation was found in the brains of the exposed male rats when compared to sham exposed male animals.
These data suggest that 0.9 and 1.8 GHz radiofrequency exposure (continuous wave) at levels below the international limits can affect the vascular permeability in the brain of male rats.

研究の種別:

研究助成

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