Study type: Medical/biological study (experimental study)

Absence of 60-Hz, 0.1-mT magnetic field-induced changes in oncogene transcription rates or levels in CEM-CM3 cells. med./bio.

Published in: Biochimica et Biophysica Acta - Gene Structure and Expression 1998; 1443 (3): 334-342
Journal partially peer-reviewed/unclear

Aim of study (acc. to author)

To assess the reproducibility of the 60 Hz magnetic field-induced transcription changes of c-fos, c-jun and c-myc oncogenes in human lymphoblastoid cells reported by Phillips et al. (publication 913).

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: 15, 30, 60 or 120 min

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration 15, 30, 60 or 120 min
Exposure setup
Exposure source
Chamber magnetic field or sham exposure was made in matching Forma 3158 incubators placed 3 m apart
Setup a pair of square Helmholtz coils (37 x 37 cm²) placed 19 cm apart; four flasks containing cells were placed within the central zone (17 x 17 x 5 cm) of the coil, where the magnetic field was uniform within 1%. The coils were energized in a buck mode for sham exposure.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.1 mT effective value - - -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

No significant difference in the investigated oncogenes transcript levels was detected at any time point.

Study character:

Study funded by

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