Exposure of Daudi cells to low-frequency magnetic fields does not elevate MYC steady-state mRNA levels. med./bio.

Aim of study (acc. to author)

Background/further details

Endpoint

• molecular biosynthesis: myc gene expression

Exposure

• • 50/60 Hz
  • magnetic field

Extended view Compact view

Methods Endpoint/measurement parameters/methodology

• molecular biosynthesis: myc gene expression (Northern blot, phosphorimager)

Main outcome of study (acc. to author)

Study funded by

• National Institute of Environmental Health Sciences (NIEHS), North Carolina, USA

Related articles

• Liu Y et al. (2013): The induction of Epstein-Barr Virus early antigen expression in Raji cells by GSM mobile phone radiation.
• Czyz J et al. (2004): Non-thermal effects of power-line magnetic fields (50 Hz) on gene expression levels of pluripotent embryonic stem cells-the role of tumour suppressor p53.
• Zhou J et al. (2002): Gene expression of cytokine receptors in HL60 cells exposed to a 50 Hz magnetic field.
• Yomori H et al. (2002): Elliptically polarized magnetic fields do not alter immediate early response genes expression levels in human glioblastoma cells.
• Lin H et al. (2001): Regulating genes with electromagnetic response elements.
• Balcer-Kubiczek EK et al. (2000): Expression analysis of human HL60 cells exposed to 60 Hz square- or sine-wave magnetic fields.
• Zhao YL et al. (1999): Increased DNA synthesis in INIT/10T1/2 cells after exposure to a 60 Hz magnetic field: a magnetic-field or a thermal effect?
• Loberg LI et al. (1999): Gene expression in human breast epithelial cells exposed to 60 Hz magnetic fields.
• Jahreis GP et al. (1998): Absence of 60-Hz, 0.1-mT magnetic field-induced changes in oncogene transcription rates or levels in CEM-CM3 cells.
• Owen RD (1998): MYC mRNA abundance is unchanged in subcultures of HL60 cells exposed to power-line frequency magnetic fields.
• Grimaldi S et al. (1997): Exposure to a 50 Hz electromagnetic field induces activation of the Epstein-Barr virus genome in latently infected human lymphoid cells.
• Harrison GH et al. (1997): Kinetics of gene expression following exposure to 60 Hz, 2 mT magnetic fields in three human cell lines.
• Jin M et al. (1997): Biological and technical variables in myc expression in HL60 cells exposed to 60 Hz electromagnetic fields.
• Lin H et al. (1996): Electromagnetic field stimulation of biosynthesis: changes in c-myc transcript levels during continuous and intermittent exposures.
• Balcer-Kubiczek EK et al. (1996): Rodent cell transformation and immediate early gene expression following 60-Hz magnetic field exposure.
• Miyakoshi J et al. (1996): Exposure to magnetic field (5 mT at 60 Hz) does not affect cell growth and c-myc gene expression.
• Lin H et al. (1995): Electric and magnetic noise blocks the 60 Hz magnetic field enhancement of steady state c-myc transcript levels in human leukemia cells.
• Lacy-Hulbert A et al. (1995): No effect of 60 Hz electromagnetic fields on MYC or beta-actin expression in human leukemic cells.
• Saffer JD et al. (1995): Short exposures to 60 Hz magnetic fields do not alter MYC expression in HL60 or Daudi cells.
• Lin H et al. (1994): Specific region of the c-myc promoter is responsive to electric and magnetic fields.
• Gold S et al. (1994): Exposure of simian virus-40-transformed human cells to magnetic fields results in increased levels of T-antigen mRNA and protein.
• Greene JJ et al. (1993): Gene-specific modulation of RNA synthesis and degradation by extremely low frequency electromagnetic fields.
• Liburdy RP et al. (1993): Experimental evidence for 60 Hz magnetic fields operating through the signal transduction cascade. Effects on calcium influx and c-MYC mRNA induction.
• Goodman R et al. (1992): Exposure to electric and magnetic (EM) fields increases transcripts in HL-60 cells: does adaptation to EM fields occur?.
• Ning J et al. (1992): Comparison of the effect of ELF on total RNA content in normal and transformed human cells.
• Phillips JL et al. (1992): Magnetic field-induced changes in specific gene transcription.
• Blank M et al. (1992): Changes in transcription in HL-60 cells following exposure to alternating currents from electric fields.
• Goodman R et al. (1992): Exposure of human cells to electromagnetic fields: effect of time and field strength on transcript levels.
• Battini R et al. (1991): ELF electromagnetic fields affect gene expression of regenerating rat liver following partial hepatectomy.
• Wei LX et al. (1990): Changes in levels of c-myc and histone H2B following exposure of cells to low-frequency sinusoidal electromagnetic fields: evidence for a window effect.
• Goodman R et al. (1989): Exposure of human cells to low-frequency electromagnetic fields results in quantitative changes in transcripts.