Study type: Medical/biological study (experimental study)

Magnetic field-induced changes in specific gene transcription. med./bio.

Published in: Biochimica et Biophysica Acta - Gene Structure and Expression 1992; 1132 (2): 140-144
Journal partially peer-reviewed/unclear

Aim of study (acc. to author)

To investigate the effects of magnetic fields on the c-fos, c-myc, c-jun and protein kinase C transcription rate in human lymphoblastoid cells.

Background/further details

The influence of exposure time and cell culture density (5x105 cells/ml and 106 cells/ml) were further investigated in order to explore their relevance on magnetic field induced changes.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 60 Hz
Exposure duration: continuous for 15, 30, 60, 90 and 120 min

Exposure 1

Main characteristics
Frequency 60 Hz
Type
Waveform
Exposure duration continuous for 15, 30, 60, 90 and 120 min
Exposure setup
Exposure source
Setup Two coils, each 38 cm in diameter, providing uniform magnetic field were mounted horizontally in an incubator and separated by a distance of 19 cm. A similar incubator was used for control cultures.
Parameters
Measurand Value Type Method Mass Remarks
magnetic flux density 0.1 mT effective value unspecified - -

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • during exposure
  • after exposure

Main outcome of study (acc. to author)

Exposure time-dependent and cell culture density-dependent changes in the transcription of c-fos, c-jun, c-myc and protein kinase C were observed.

Study character:

Study funded by

Replication studies

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