The c-myctranscript levels were further analysed in regard to: 1. a change to the steady state transcript levels, 2. the return to control levels, 3. the influence of a second stimulus with the same or different field strength, 4. the occurrence of a refractory period and 5. the occurrence of an "acquired tolerance".
The magnetic field was generated by a pair of coils consisting of 164 turns of 19 gauge copper wire which was wound around a 13 x 14 cm Plexiglass form with in an 8 cm space. The exposure system was placed in a µ-metal container. The flasks were placed horizontally on a Plexiglass stand in an homogeneous area of the coil. sham exposure took place simultaneously in the same incubator which was also shielded with a µ-metal container.
Czyz J et al.
(2004):
Non-thermal effects of power-line magnetic fields (50 Hz) on gene expression levels of pluripotent embryonic stem cells-the role of tumour suppressor p53.
Yomori H et al.
(2002):
Elliptically polarized magnetic fields do not alter immediate early response genes expression levels in human glioblastoma cells.
Jahreis GP et al.
(1998):
Absence of 60-Hz, 0.1-mT magnetic field-induced changes in oncogene transcription rates or levels in CEM-CM3 cells.
Owen RD
(1998):
MYC mRNA abundance is unchanged in subcultures of HL60 cells exposed to power-line frequency magnetic fields.
Harrison GH et al.
(1997):
Kinetics of gene expression following exposure to 60 Hz, 2 mT magnetic fields in three human cell lines.
Jin M et al.
(1997):
Biological and technical variables in myc expression in HL60 cells exposed to 60 Hz electromagnetic fields.
Balcer-Kubiczek EK et al.
(1996):
Rodent cell transformation and immediate early gene expression following 60-Hz magnetic field exposure.
Miyakoshi J et al.
(1996):
Exposure to magnetic field (5 mT at 60 Hz) does not affect cell growth and c-myc gene expression.
Lacy-Hulbert A et al.
(1995):
No effect of 60 Hz electromagnetic fields on MYC or beta-actin expression in human leukemic cells.
Lin H et al.
(1995):
Electric and magnetic noise blocks the 60 Hz magnetic field enhancement of steady state c-myc transcript levels in human leukemia cells.
Saffer JD et al.
(1995):
Short exposures to 60 Hz magnetic fields do not alter MYC expression in HL60 or Daudi cells.
Lin H et al.
(1994):
Specific region of the c-myc promoter is responsive to electric and magnetic fields.
Gold S et al.
(1994):
Exposure of simian virus-40-transformed human cells to magnetic fields results in increased levels of T-antigen mRNA and protein.
Greene JJ et al.
(1993):
Gene-specific modulation of RNA synthesis and degradation by extremely low frequency electromagnetic fields.
Liburdy RP et al.
(1993):
Experimental evidence for 60 Hz magnetic fields operating through the signal transduction cascade. Effects on calcium influx and c-MYC mRNA induction.
Goodman R et al.
(1992):
Exposure of human cells to electromagnetic fields: effect of time and field strength on transcript levels.
Blank M et al.
(1992):
Changes in transcription in HL-60 cells following exposure to alternating currents from electric fields.
Goodman R et al.
(1992):
Exposure to electric and magnetic (EM) fields increases transcripts in HL-60 cells: does adaptation to EM fields occur?.
Ning J et al.
(1992):
Comparison of the effect of ELF on total RNA content in normal and transformed human cells.
Battini R et al.
(1991):
ELF electromagnetic fields affect gene expression of regenerating rat liver following partial hepatectomy.
Wei LX et al.
(1990):
Changes in levels of c-myc and histone H2B following exposure of cells to low-frequency sinusoidal electromagnetic fields: evidence for a window effect.
Goodman R et al.
(1989):
Exposure of human cells to low-frequency electromagnetic fields results in quantitative changes in transcripts.
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