この研究は、900 MHz GSM変調電磁界への毎日の全身ばく露が、C57BL/6マウスの脾臓リンパ球に影響を与えるか否かを調べた。マウスは、TEMセル内で、SARが1または2 W/ kgの電磁界ばく露を、2時間／日で、1、2または4週間、受けた。無処置群、擬似ばく露群も実験に含めた。全ての動物は、ばく露（擬似ばく露）終了後に屠殺し、脾臓細胞を採取した。その結果、脾臓細胞の数、B細胞とT細胞の割合、T細胞亜集団（CD4とCD8）の分布は、ばく露によって変化しなかった；採取されたTおよびB細胞を、ex vivoで、特定のモノクローナル抗体またはLPSで刺激し、細胞増殖、サイトカイン産生、活性化マーカーの発現の誘導を観察したが、Tリンパ球またはBリンパ球のどちらにおいても、ばく露群と擬似ばく露群の間に大きな違いは見られなかった；1または2 W / kgへの1週間のばく露後、IFN-γ（インターフェロンγ）産生の増加が観察されたが、2または4週間のばく露後には見られなかった；これは、他のストレス因子と同様に、免疫系がRF放射に適応した可能性があることを示唆する、と報告している。
The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →
To evaluate whether daily whole-body exposure of mice to 900 MHz GSM-modulated irradiation could affect spleen lymphocytes. T cells and B cells were stimulated ex vivo using specific monoclonal antibodies or lipopolysaccharides to induce cell proliferation, cytokine production and expression of activation markers.
|ばく露時間||repeated daily exposure, 2 h/day for 1, 2 or 4 weeks|
basic GSM modulation
|ばく露装置の詳細||Mice were housed individually in transparent Perspex jigs with openings to provide air circulation. Four mice were placed in the cell (two above and two below the septum with daily clockwise rotation) with their caudal axis parallel to the direction of propagation.|
|Additional information||A blinded procedure was used for exposure. Sham-exposed mice experienced the same conditions except for the EMF. A control group was kept with minimal handling. A water cooling system was set up with two external metal jackets filled with circulating water fed through a thermostatic bath (20°C) and placed in contact with the bottom walls. The maximum difference between exposed and sham-exposed groups was < 0,5°C.|
The number of spleen cells, the percentages of B cells and T cells, and the distribution of T cell subpopulations were not changed by irradiation. The findings did not show relevant differences in either T lymphocytes or B lymphocytes from animals exposed to an SAR of 1 or 2 W/kg and sham-exposed animals with few exceptions. After 1 week of exposure to 1 or 2 W/kg, an increase in IFN-gamma production was revealed that was not evident when the irradiation was prolonged to 2 or 4 weeks. This indicates that the immune system might have adapted to radiofrequency irradiation as it does with other stressing agents.
In conclusion, the in vivo data indicate that the T cell and B cell compartments were not substantially affected by radiofrequency irradiation and that a clinically relevant effect of the irradiation on the immune system is unlikely to occur.