研究のタイプ: 医学/生物学の研究 (experimental study)

[子宮内および出生後早期のラットのWi-Fi信号へのばく露:血清免疫マーカのスクリーニングおよび妊娠の結末] med./bio.

In utero and early-life exposure of rats to a Wi-Fi signal: Screening of immune markers in sera and gestational outcome.

掲載誌: Bioelectromagnetics 2012; 33 (5): 410-420

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研究目的(著者による)

To test the hypothesis that exposure to radiofrequency electromagnetic fields may impact the production of neoantigens in developing organisms, the authors investigated sera of young rats exposed from the gestational period until sexual maturity.

詳細情報

The period of exposure (from the 6th gestational day to 5 weeks postnatal) covered development of the immune system mainly occurring in utero and its maturation postnatal.
Pregnant rats were exposed at different specific absorption rates (each exposure condition 10-12 rats). Dams were exposed from days 6 to 21 of gestation and together with three newborns (two males, one female) per litter from birth until weaning (postnatal day 21). Then, dams were removed and the three pups were exposed from day 21 until postanatal day 35. On day 35 after birth, all pups were sacrificed and sera collected. One male per litter was used to obtain serum samples (sham exposure group: n=10; 0.08 W/kg group: n=10; 0.4 W/kg group: n=12; 4 W/kg group: n=9 and cage control: n=11).
Positive controls were performed by using an arthritis rat model using Mycobacterium tuberculosis H37RA in male Wistar rats (n=3).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
ばく露時間: continuous 2h/day, 5 days/week from day 6 to 21 of gestation (pregnant dam) and from day 1 to 35 (pups) postnatal
  • SAR: 4 W/kg average over mass (whole body) (11 dams)
  • SAR: 0.4 W/kg average over mass (whole body) (12 dams)
  • SAR: 0.08 W/kg average over mass (whole body) (10 dams)
  • SAR: 0 W/kg average over mass (whole body) (10 dams)
  • SAR: 9 W/kg maximum (whole body) (+/- 3 W/kg; max. SAR of pups)

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
ばく露時間 continuous 2h/day, 5 days/week from day 6 to 21 of gestation (pregnant dam) and from day 1 to 35 (pups) postnatal
ばく露装置
ばく露の発生源/構造
チャンバの詳細 cubic reverberation chamber (150 cm x 150 cm x 150 cm) with six antennas, respectively one in the middle of each side of the cube
ばく露装置の詳細 the six antennas were activated at random; three stirrers used for mode mixing to obtain symmetrical and uniform exposure; WiFi-signal was amplified by a 70 W power amplifier to reach the different SAR values
Sham exposure A sham exposure was conducted.
Additional information four animal cages with the exposure groups were placed in a 40 cm x 40 cm x 40 cm volume at the centre of the chamber
パラメータ
測定量 種別 Method Mass 備考
SAR 4 W/kg average over mass 測定値および計算値 whole body 11 dams
SAR 0.4 W/kg average over mass 測定値および計算値 whole body 12 dams
SAR 0.08 W/kg average over mass 測定値および計算値 whole body 10 dams
SAR 0 W/kg average over mass 測定値および計算値 whole body 10 dams
SAR 9 W/kg maximum 計算値 whole body +/- 3 W/kg; max. SAR of pups

Reference articles

  • Wu T et al. (2010): [2.4GHzで動作する反響チャンバでの新生仔および若年のラットの全身ばく露評価]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

Under these experimental conditions, whole-body in utero and extended postnatal exposure of rats to a WiFi signal at SAR levels up to 4 W/kg for the dams and transiently up to 9 W/kg for the pups had no detectable effects on the production of immunoglobulins directed against the selected antigens related to several pathological processes or on the gestational outcome (i.e. number of pups per litter, body weights of pups).

研究の種別:

研究助成

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