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To test the hypothesis that exposure to radiofrequency electromagnetic fields may impact the production of neoantigens in developing organisms, the authors investigated sera of young rats exposed from the gestational period until sexual maturity.
The period of exposure (from the 6th gestational day to 5 weeks postnatal) covered development of the immune system mainly occurring in utero and its maturation postnatal.
Pregnant rats were exposed at different specific absorption rates (each exposure condition 10-12 rats). Dams were exposed from days 6 to 21 of gestation and together with three newborns (two males, one female) per litter from birth until weaning (postnatal day 21). Then, dams were removed and the three pups were exposed from day 21 until postanatal day 35. On day 35 after birth, all pups were sacrificed and sera collected. One male per litter was used to obtain serum samples (sham exposure group: n=10; 0.08 W/kg group: n=10; 0.4 W/kg group: n=12; 4 W/kg group: n=9 and cage control: n=11).
Positive controls were performed by using an arthritis rat model using Mycobacterium tuberculosis H37RA in male Wistar rats (n=3).
ばく露時間: continuous 2h/day, 5 days/week from day 6 to 21 of gestation (pregnant dam) and from day 1 to 35 (pups) postnatal
|ばく露時間||continuous 2h/day, 5 days/week from day 6 to 21 of gestation (pregnant dam) and from day 1 to 35 (pups) postnatal|
|チャンバの詳細||cubic reverberation chamber (150 cm x 150 cm x 150 cm) with six antennas, respectively one in the middle of each side of the cube|
|ばく露装置の詳細||the six antennas were activated at random; three stirrers used for mode mixing to obtain symmetrical and uniform exposure; WiFi-signal was amplified by a 70 W power amplifier to reach the different SAR values|
|Sham exposure||A sham exposure was conducted.|
|Additional information||four animal cages with the exposure groups were placed in a 40 cm x 40 cm x 40 cm volume at the centre of the chamber|
|SAR||4 W/kg||average over mass||測定値および計算値||whole body||11 dams|
|SAR||0.4 W/kg||average over mass||測定値および計算値||whole body||12 dams|
|SAR||0.08 W/kg||average over mass||測定値および計算値||whole body||10 dams|
|SAR||0 W/kg||average over mass||測定値および計算値||whole body||10 dams|
|SAR||9 W/kg||maximum||計算値||whole body||+/- 3 W/kg; max. SAR of pups|
Under these experimental conditions, whole-body in utero and extended postnatal exposure of rats to a WiFi signal at SAR levels up to 4 W/kg for the dams and transiently up to 9 W/kg for the pups had no detectable effects on the production of immunoglobulins directed against the selected antigens related to several pathological processes or on the gestational outcome (i.e. number of pups per litter, body weights of pups).