この研究は、マウスにGSM変調900 MHz RF電磁界の全身ばく露を与え、B細胞の末梢分化および抗体産生への影響を調べた。RFばく露は、全身平均SARが2 W / kgで、2時間/日で、連続4週間継続した。その結果、脾臓での分化の1型移行期（T1）および2型移行期（T2）B細胞の頻度にも、成熟濾胞B細胞や辺縁帯B細胞の頻度にもRFばく露は影響しなかった；IgMとIgGの血清レベルも、ばく露マウス、擬似ばく露マウス、および対照マウスの間で有意差はなかった；これらのマウスのB細胞に、インビトロでLPSの刺激を与えると、同等の量のIgMとIgGを産生した；さらに、免疫されたマウスにRF電磁界ばく露を与えても、抗原特異抗体の血清レベルは変化しなかった；抗原特異的なIgMの生成だけでなく、IgG（T-B細胞相互作用を必要とする）の生成もRF電磁界の影響を受けない；これは、RFばく露が体内で進行中の抗原特異的な免疫応答を変化させないことを示している、と報告している。
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Modulation type: pulsed
ばく露時間: repeated daily exposure, 2 h/day, 5 days/week, for 4 weeks
A detailed description of the exposure system and the dosimetry assessment has been published in [Ardoino et al., 2005].
|ばく露時間||repeated daily exposure, 2 h/day, 5 days/week, for 4 weeks|
GSM basic modulation
|チャンバの詳細||Two non-standard TEM cells (12 x 12 x 120 cm) were designed according to electromagnetic restraints and optimization of the uniform field volume [Van Hese et al., 1992]. They had a grid wall for air circulation. A water cooling system with two external metal jackets filled with circulating water fed from a thermostatic bath was placed in contact with the bottom walls of the TEM cell.|
|ばく露装置の詳細||Mice restrained in ventilated transparent cylindrical Perspex jigs were positioned with their caudal axis parallel to the direction of the field propagation. The jigs were placed under and over the septum and kept at the same distance by polystyrene supports.|
|Sham exposure||A sham exposure was conducted.|
|Additional information||Eight mice at a time were placed in a TEM cell with daily clockwise rotation of their location to increase the homogeneity of exposure. The people preparing the biological samples and performing the biological tests did not know which TEM cell was activated. Control mice were maintained in the animal facility with minimal handling.|
|SAR||2 W/kg||mean||測定値および計算値||whole body||-|
Under the experimental conditions used, the data showed no effect of in vivo exposure to GSM modulated radiofrequency fields on B cell peripheral differentiation or on antibody production in response to both polyclonal activators and antigens. This indicates that it is unlikely that radiofrequency field exposure alters immune response to infections or vaccination.