研究のタイプ: 医学／生物学の研究 (experimental study)

[835 MHzの電磁放射はヒト星状細胞腫細胞株の形態を変化させ、増殖を阻害する] med./bio.

Electromagnetic radiation at 835 MHz changes the morphology and inhibits proliferation of a human astrocytoma cell line

著者: French PW, Donnellan M, McKenzie DR
掲載誌: Bioelectrochem Bioenerg 1997; 43 (1): 13-18
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この研究は、ヒトの星状細胞腫細胞株U-87 MGに、835MHz電磁放射を1回20分間、1日3回、7日間与え、影響を調べた。電力密度は、40±15 mW cm-2または8.1±3 mWcm-2であった。その結果、電力密度8.1mWcm-2群では、無ばく露対照群に比べ、DNA合成の速度低下、および細胞の平坦化と広がりが観察された；40mWcm-2群では、細胞増殖に影響は見られなかったが、細胞の広がり増加、膜の局在部位でのアクチン含有ブレブ出現などの細胞形態の変化が見られた、と報告している。

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研究目的（著者による）

To examine the effects of a continuous electromagnetic field on cellular characteristics such as cell proliferation and morphology in cultured human astrocytoma cells in vitro.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 864.3 MHz
Modulation type: CW
ばく露時間: repeated daily exposure, 3 x 20 min/day (at 4-h intervals), for 7 days
ばく露2: 864.3 MHz
Modulation type: CW
ばく露時間: repeated daily exposure, 3 x 20 min/day (at 4-h intervals), for 7 days

ばく露1

主たる特性
周波数 864.3 MHz
タイプ
  • electromagnetic field
波形
  • sinusoidal
ばく露時間 repeated daily exposure, 3 x 20 min/day (at 4-h intervals), for 7 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 The samples in 75 cm² culture flasks were placed on a wooden platform and 0.04 m above the mid-plane of an aluminium box of 1.10 m internal side length. The antenna was mounted horizontally at the centre of the mid-plane.
Sham exposure A sham exposure was conducted.
Additional information The antenna produced a magnetic field on the mid-plane of the box, essentially along the vertical or z-axis direction of the box. The electric field was transverse in the xy plane. Control cells were placed in the Faraday cage but without irradiation.
パラメータ
測定量 値 種別 Method Mass 備考
電力 2 W - - - -
電力密度 2.4 mW/cm² spatial average 測定値 - -
電力密度 8.1 mW/cm² maximum 測定値 - ± 3 mW/cm²
SAR 8.96 W/kg mean 測定値 - -
Additional parameter details

The maximum power density measured using two broadband field strength meters was 8.1 mW/cm² and 9.6 mW/cm², respectively.

測定および計算の詳細

The SAR value indicated being an average of three point measurements (4.94, 11.5 and 12.1 W/kg) and a power loss measurement (7.3 W/kg) was taken as the best estimate.

ばく露2

主たる特性
周波数 864.3 MHz
タイプ
  • electromagnetic field
波形
  • sinusoidal
ばく露時間 repeated daily exposure, 3 x 20 min/day (at 4-h intervals), for 7 days
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
パラメータ
測定量 値 種別 Method Mass 備考
電力 10 W - - - -
電力密度 40 mW/cm² maximum 測定値 - ± 15 mW/cm²

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

It could be demonstrated that exposure of an astrocytoma cell line to an electromagnetic field is capabel of altering cell morphology and of inhibiting cell proliferation, as indicated by DNA synthesis, at power densities similar to those emitted by mobile cell phones. At 5-fold higher power densities, no effect on cell proliferation was observed, although cell morphology was altered.

研究の種別:

研究助成

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