研究のタイプ: 医学／生物学の研究 (experimental study)

[3G携帯電話信号へのばく露は脳腫瘍細胞の生物学的特性に影響しない] med./bio.

Exposure to 3G mobile phone signals does not affect the biological features of brain tumor cells

著者: Liu YX, Li GQ, Fu XP, Xue JH, Ji SP, Zhang ZW, Zhang Y, Li AM
掲載誌: BMC Public Health 2015; 15: 764
RISフォーマットで参考文献をダウンロード

この研究は、ヒト神経膠芽腫細胞株（U251-MG およびU87-MG）を用いて、携帯電話電磁界（1950MHz TD-SCDMA：最大SAR値5.0W/kg：ばく露時間12、24、48時間）がそれらの細胞の生物学的特性に変化を与えるか、腫瘍プロモーション作用を持つか否かを調べた。その結果、ばく露群と無ばく露群の間に、生物学的特性の変化または腫瘍プロモーション作用のどちらにおいても有意差は見られなかった、と報告している。

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研究目的（著者による）

The effects of exposure of human glioblastoma cell lines to a 1950 MHz electromagnetic field on cellular parameters and tumorigenesis should be investigated.

詳細情報

Cells of each cell line (U251, U87, T98 and A127) were divided into the following groups: exposure for 1) 12 hours, 2) 24 hours, 3) 48 hours and 4) control group (remark EMF-Portal: partially also referred to as sham exposure, no details given on procedure).
After exposure, U251 and U87 cells from all groups were injected subcutaneously into nude mice (n=3 mice per group). After 28 days, mice were sacrificed and developed tumors were quantified and investigated.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1,950 MHz
ばく露時間: continuous for 12 hours
  • SAR: 5 W/kg average over mass (10 g) (max value)
  • 電力: 250 mW maximum (nominal maximum power fed to the antenna)
ばく露2: 1,950 MHz
ばく露時間: continuous for 24 hours
  • SAR: 5 W/kg average over mass (10 g) (max value)
  • 電力: 250 mW maximum (nominal maximum power fed to the antenna)
ばく露3: 1,950 MHz
ばく露時間: continuous for 48 hours
  • SAR: 5 W/kg average over mass (10 g) (max value)
  • 電力: 250 mW maximum (nominal maximum power fed to the antenna)

ばく露1

主たる特性
周波数 1,950 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 12 hours
Additional information 1950 MHz is the median value of TD-SCDMA mobile phones of Band A (2010-2025 MHz) and Band F (1880-1920 MHz)
ばく露装置
ばく露の発生源／構造
Distance between exposed object and exposure source 10 mm
チャンバの詳細 25 cm cell culture bottles (or 25 mm plates? contradictory statements)
ばく露装置の詳細 antenna was placed under up to four bottles simultaneously in an incubator; temperature of the cell plates was maintained at 37°C
パラメータ
測定量 値 種別 Method Mass 備考
SAR 5 W/kg average over mass 計算値 10 g max value
電力 250 mW maximum 測定値 - nominal maximum power fed to the antenna
Additional parameter details

maximum background magnetic field in the incubator was 0.7 µT

ばく露2

主たる特性
周波数 1,950 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 24 hours
Additional information 1950 MHz is the median value of TD-SCDMA mobile phones of Band A (2010-2025 MHz) and Band F (1880-1920 MHz)
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Distance between exposed object and exposure source 10 mm
パラメータ
測定量 値 種別 Method Mass 備考
SAR 5 W/kg average over mass 計算値 10 g max value
電力 250 mW maximum 測定値 - nominal maximum power fed to the antenna
Additional parameter details

maximum background magnetic field in the incubator was 0.7 µT

ばく露3

主たる特性
周波数 1,950 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 48 hours
Additional information 1950 MHz is the median value of TD-SCDMA mobile phones of Band A (2010-2025 MHz) and Band F (1880-1920 MHz)
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Distance between exposed object and exposure source 10 mm
パラメータ
測定量 値 種別 Method Mass 備考
SAR 5 W/kg average over mass 計算値 10 g max value
電力 250 mW maximum 測定値 - nominal maximum power fed to the antenna
Additional parameter details

maximum background magnetic field in the incubator was 0.7 µT

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

No significant differences were observed between the exposure groups (groups 1-3) and the control group (group 4).
The authors conclude that exposure of human glioblastoma cell lines to a 1950 MHz electromagnetic field has no effect on cellular parameters and tumorigenesis.

研究の種別:

研究助成

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