この研究は、ラット脳グリオーマモデルを用いて、電磁界（EMF）の腫瘍プロモート作用の可能性を調べた。ばく露に用いたのは、915MHzマイクロ波の連続波（1W）および2種類のパルス変調波（パルス幅0.5ms、パルス繰り返し周波数4、8、16、200Hz;パルス幅6ms、パルス繰り返し周波数50Hz（1パルス当たり2W）である。フィッシャー344ラット（オスおよびメス、体重150〜250g）を用いた。定位固定術により、ばく露群および対照群（各n = 38）の右尾状核頭部にRG2細胞（5000個、5 µlの栄養溶液）を注入移植した。無麻酔でのばく露は、換気機能付きのTEMセル内で行われた。RG2細胞移植後5日目にばく露を開始し、7時間／日、5日／週で2〜3週間、継続した。すべての脳を組織病理学的に検査し、腫瘍の大きさを決定した。その結果、ばく露群と対照群で、腫瘍の大きさに有意な差はなかった、と報告している。
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To investigate the effects of electromagnetic field exposure in a rat brain glioma model.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
915 MHz
Modulation type:
CW
ばく露時間:
repeated daily exposure, 7 h/day, 5 days/week, for 10-15 days
|
|
|
ばく露2:
915 MHz
Modulation type:
pulsed
ばく露時間:
repeated daily exposure, 7 h/day, 5 days/week, for 10 days
|
|
|
ばく露3:
915 MHz
Modulation type:
pulsed
ばく露時間:
repeated daily exposure, 7 h/day, 5 days/week, for 10 days
|
|
|
ばく露4:
915 MHz
Modulation type:
pulsed
ばく露時間:
repeated daily exposure, 7 h/day, 5 days/week, for 13 days
|
|
|
ばく露5:
915 MHz
Modulation type:
pulsed
ばく露時間:
repeated daily exposure, 7 h/day, 5 days/week, for 9 days
|
|
|
ばく露6:
915 MHz
Modulation type:
pulsed
ばく露時間:
repeated daily exposure, 7 h/day, 5 days/week, for 9-13 days
|
| 周波数 | 915 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | repeated daily exposure, 7 h/day, 5 days/week, for 10-15 days |
| Modulation type | CW |
|---|
| ばく露の発生源／構造 | |
|---|---|
| ばく露装置の詳細 | Unanaesthetized animals were exposed in well ventilated TEM cells for 7 h per day with a 30-min break after 4 h for feeding and stretching. |
| Sham exposure | A sham exposure was conducted. |
| Additional information | Control animals were kept in identical TEM cells without EMF exposure. |
| 周波数 | 915 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | repeated daily exposure, 7 h/day, 5 days/week, for 10 days |
| Modulation type | pulsed |
|---|---|
| Pulse width | 0.57 ms |
| Duty cycle | 0.2 % |
| Repetition frequency | 4 Hz |
| ばく露の発生源／構造 | |
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 915 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | repeated daily exposure, 7 h/day, 5 days/week, for 10 days |
| Modulation type | pulsed |
|---|---|
| Pulse width | 0.57 ms |
| Duty cycle | 0.5 % |
| Repetition frequency | 8.33 Hz |
| ばく露の発生源／構造 | |
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 915 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | repeated daily exposure, 7 h/day, 5 days/week, for 13 days |
| Modulation type | pulsed |
|---|---|
| Pulse width | 0.57 ms |
| Duty cycle | 0.9 % |
| Repetition frequency | 16 Hz |
| ばく露の発生源／構造 | |
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 915 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | repeated daily exposure, 7 h/day, 5 days/week, for 9 days |
| Modulation type | pulsed |
|---|---|
| Pulse width | 0.57 ms |
| Duty cycle | 12 % |
| Repetition frequency | 217 Hz |
| ばく露の発生源／構造 | |
|---|---|
| Sham exposure | A sham exposure was conducted. |
| 周波数 | 915 MHz |
|---|---|
| タイプ |
|
| 特性 |
|
| ばく露時間 | repeated daily exposure, 7 h/day, 5 days/week, for 9-13 days |
| Modulation type | pulsed |
|---|---|
| Pulse width | 6 ms |
| Duty cycle | 30 % |
| Repetition frequency | 50 Hz |
| ばく露の発生源／構造 | |
|---|---|
| Sham exposure | A sham exposure was conducted. |
The results does not show a significant difference in tumor size between animals exposed to 915 MHz microwaves, and those not exposed. The rectal temperature recorded before, at 4h and directly after exposure did not fall or rise.
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