研究のタイプ: 医学/生物学の研究 (experimental study)

[長期マイクロ波ばく露による損傷をWistarラットの尿で検出するための(1)H-NMRに基づくメタボロミクスの応用] med./bio.

Application of (1)H-NMR-based metabolomics for detecting injury induced by long-term microwave exposure in Wistar rats' urine.

掲載誌: Anal Bioanal Chem 2012; 404 (1): 69-78

The detailed summary of this article is not available in your language or incomplete. Would you like to see a complete translation of the summary? Then please contact us →

研究目的(著者による)

The study aimed to identify sensitive urinary biomarkers for the detection of injury induced by microwave exposure in rats using 1H NMR.

詳細情報

20 rats were exposed and 20 rats were sham exposed. Urine samples were collected over a 24 h period in metabolic cages at 7 days, 21 days, 2 months, and 6 months after exposure (5 animals/time point).

影響評価項目

ばく露

ばく露 パラメータ
ばく露1:
  • unspecified
ばく露時間: continuous for 6 min/day, 5 days/week during one month
  • 電力密度: 5 mW/cm² average over time
  • SAR: 2.1 W/kg average over mass (whole body)

ばく露1

主たる特性
周波数
  • unspecified
タイプ
  • electromagnetic field
ばく露時間 continuous for 6 min/day, 5 days/week during one month
ばく露装置
ばく露の発生源/構造
  • 詳細不明
ばく露装置の詳細 rats kept in individual polypropylene cages during exposure
Sham exposure A sham exposure was conducted.
パラメータ
測定量 種別 Method Mass 備考
電力密度 5 mW/cm² average over time - - -
SAR 2.1 W/kg average over mass - whole body -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Urine metabolic profiles of exposed rats were significantly different from those of sham exposed animals at 7 days, 21 days, and 2 months after exposure. Metabolites returned to normal levels six months after exposure.
These data indicate that energy metabolism, particularly the tricarboxylic acid cycle, and amino acid, monoamine, and choline metabolism, were affected by long-term microwave exposure. Furthermore, metabolites of neurotransmitters (taurine, hippurate, phenylalanine, and tyrosine) were identified in urine as potential biomarkers of injury induced by long-term microwave exposure.

研究の種別:

研究助成

関連論文