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The study aimed to identify sensitive urinary biomarkers for the detection of injury induced by microwave exposure in rats using 1H NMR.
20 rats were exposed and 20 rats were sham exposed. Urine samples were collected over a 24 h period in metabolic cages at 7 days, 21 days, 2 months, and 6 months after exposure (5 animals/time point).
|ばく露時間||continuous for 6 min/day, 5 days/week during one month|
|ばく露装置の詳細||rats kept in individual polypropylene cages during exposure|
|Sham exposure||A sham exposure was conducted.|
Urine metabolic profiles of exposed rats were significantly different from those of sham exposed animals at 7 days, 21 days, and 2 months after exposure. Metabolites returned to normal levels six months after exposure.
These data indicate that energy metabolism, particularly the tricarboxylic acid cycle, and amino acid, monoamine, and choline metabolism, were affected by long-term microwave exposure. Furthermore, metabolites of neurotransmitters (taurine, hippurate, phenylalanine, and tyrosine) were identified in urine as potential biomarkers of injury induced by long-term microwave exposure.