【目的】CDMA（849 MHz）およびWCDMA（1.95 GHz）方式の無線周波（RF）への1年間の長期同時ばく露がSD（Sprague-Dawley）系ラットに慢性疾病を誘導するか否かを調べること。【方法】SD系ラット40匹（オス50%、メス50％）のばく露群と擬似ばく露群に、CDMAおよびWCDMAのRF同時ばく露（それぞれ2.0 W/kg、計4.0 W/kg）を1日当たり45分間、毎週5日間、全体で1年間行った。体重と臓器重量の測定、尿分析、血液学的分析、血液生化学的分析、病理組織学的評価を実施した。【結果】ばく露群のオスおよびメスの死亡率パターンは、性別をマッチさせた擬似ばく露群のものと同等であった。同時組み合わせばく露に伴った体重の有意な変化は観察されなかった。ばく露群の大半のラットは、尿分析、血液学、血液生化学、病理組織学に基づく有意な変化を示さなかった。ただし、ばく露群において、全血球計算値および血清化学のパラメータの一部に変化が見られた。全がん発生率は、ばく露群と擬似ばく露群で違いがなかった。【結論】今回の実験条件での1年間のCDMAおよびWCDMAへの同時ばく露で、ラットでの慢性疾病は増加しなかった。ただし、全血球計算値および血清化学のパラメータの一部に変化が見られた。注：この研究者グループは、同じ研究デザインで、リンパ腫のモデル動物であるAKR/Jマウスについての42週間ばく露の研究も公表している。
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To study whether one-year, long-term, simultaneous exposure to CDMA (849 MHz) and W-CDMA (1.95 GHz) radiofrequencies would induce chronic illness in rats.
The animals were divided into the following four groups (n=20/group): 1) male sham exposure group, 2) male combined radiofrequency exposure group, 3) female sham exposure group, and 4) female combined radiofrequency exposure group.
rats were treated in four groups: i) male sham exposure ii) male combined RF exposure iii) female sham exposure iv) female combined RF exposure
| 周波数 | 849 MHz–1.95 GHz |
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| タイプ |
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| ばく露時間 | continuous for 45 min/day, 5 days/week for 12 months |
| Additional information | combined exposure to f = 849 MHz (CDMA) and f = 1.95 GHz (WCDMA) |
| ばく露の発生源／構造 |
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| チャンバの詳細 | 2295 mm x 2293 mm x 1470 mm reverberation chamber with stainless walls; five cages placed in the exposure chamber; two rats placed in a 420 mm x 260 mm x 160 mm autoclaved polycarbonate cage; cage positions changed daily |
| Sham exposure | A sham exposure was conducted. |
No animal died during the 12-month experimental period. No significant alterations in body and organ weights were observed under the simultaneous combined radiofrequency exposure. The data did not show any significant alterations based on urinalysis, haematology, blood biochemistry, or histopathology in most of the rats. The total tumour incidence was not different between sham exposed and exposed animals.
However, some altered parameters of the blood count and serum chemistry were found in radiofrequency exposed rats: The mean corpuscular haemoglobin in radiofrequency-exposed male rats was significantly increased compared with the sham exposed rats (however, no significant difference was observed in female rats). Additionally, the value of alkaline phosphatase was significantly increased only in radiofrequency exposed male rats and the values of total bilirubin and lactate dehydrogenase were decreased only in radiofrequency exposed female rats with statistical significance.
In conclusion, the data suggest that one-year chronic exposure to CDMA (849 MHz) and WCDMA (1.95 GHz) simultaneously did not increase chronic illness in rats, although there were some altered parameters in the blood count and serum chemistry.
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