この研究は、ラットを用いた実験で、超低周波磁界（ELF-MF; 50 Hz、1 mT）ばく露およびマンガンの投与が、ラットの頭と顎の骨におけるミネラル蓄積に与える影響を調べた。以前の研究で、マンガンがカルシウムとリンの会合に寄与するとともに、エナメル質と象牙質の正常な発達に重要な役割を果たすことが報告されていることを踏まえ、マンガンの毎日投与も実験に組み入れた。64匹のオスのウィスターアルビノラットを8群に分けた。第1-3群はマグネシウム投与群（体重1 kg当たり60 mg、15 mg、3.75 mg）、第4群はELF-MF群、第5-7群はマグネシウム投与（体重1 kg当たり60 mg、15 mg、3.75 mg）+ ELF-MF群、第8群はケージ対照群である。その結果、第1-6群において、頭と顎の骨でのミネラル量の有意な増加が示されるとともに、歯での組織学的変化が見られた、と報告している。
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To examine whether extremely low frequency magnetic fields and manganese administration influence the mineral accumulation in cranial and jaw bones of rats.
64 rats were divided into 8 groups of rats: rats from groups 1-3 were administered manganese (60 mg, 15 mg, or 3.75 mg per kg body weight), rats from group 4 were exposed to a magnetic field, rats from group 5-7 were administered manganese (60 mg, 15 mg, or 3.75 mg per kg body weight) and exposed to a magnetic field, and group 8 was handled as a cage control. Manganese was administered daily during the exposure period.
| ばく露 | パラメータ |
|---|---|
|
ばく露1:
50 Hz
ばく露時間:
continuous for 4 h/day on 45 days
|
|
rats were divided into the following eight groups: 1.) administration of 60 mg/kg Mn 2.) administration of 15 mg/kg Mn 3.) administration of 3.75 mg/kg Mn 4.) EMF exposure 5.) administration of 60 mg/kg Mn + EMF exposure 6.) administration of 15 mg/kg Mn + EMF exposure 7.) administration of 3.75 mg/kg Mn + EMF exposure 8.) cage control
In rats that received 60 mg or 15 mg manganese per kg body weight daily (group 1, 2, 5, 6), the bone density in the anterior jaw was significantly increased after the exposure/treatment period compared to before. In the cranium, the bone density was significantly increased in group 1, 4, and 5 after the 45 days of treatment compared to the starting value. When the treatment groups were compared to the cage control after 45 days, the bone density of all rats was significantly increased in the anterior jaw and in the whole cranium.
While the oral tissue of the cage control group appeared normal, magnetic field exposed groups (group 4-7) showed histopathological alterations (dilated blood vessels, changes in the connective tissue). Additionally, in oral tissue of rats that were administered manganese (group 1-2) histopathological changes (in connective tissue) occurred, while samples of group 3 appeared almost normal.
The authors conclude that extremely low frequency magnetic fields and manganese could influence the bone density of the rat jaw and cranium, but that further studies are required to confirm the results.
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