この研究は、サフラン（学名Crocus Sativus L.）と低周波磁界（50 Hz, 0.004 T）の組合せばく露がMCF7細胞株での血管内皮増殖因子受容器（VEGFR2）の遺伝子発現に影響するか否かを調べた。種々の濃度のサフラン抽出液でMCF7細胞を処置した48時間後に、全てのフラスコに低周波磁界のばく露を与えた。VEGFR2の発現レベルをRT-PCRで分析した。その結果、サフラン抽出液処置群ではVEGER2の発現レベルが低下した；EMFばく露はサフランの血管新生抑制作用を増強させた、と報告している。
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To investigate the potentially synergistic effects of saffron and extremely low frequency magnetic fields on gene expression of the vascular endothelial growth factor 2 (VEGFR2) in human breast cancer cells.
The vascular endothelial growth factor 2 is known to be involved in the angiogenesis. A reduced expression of this growth factor could inhibit the angiogenesis in tumors and therefore inhibit the tumor growth.
Human breast cancer cells were subjected to different treatments: 1.) cultivation without treatment (control group), 2.) cultivation in the presence of saffron (100, 200, 400 and 800 µg/ml), 3.) magnetic field exposure and 4.) magnetic field exposure + saffron (100, 200, 400 and 800 µg/ml).
In magnetic field exposed cells as well as in cells cultivated in the presence of saffron, the gene expression level of the vascular endothelial growth factor was significantly decreased in comparison to the control group. A combination (co-exposure) of both treatments led to a further decrease in the expression level, which indicates a synergistic effect. No results are stated regarding cell viability and cell morphology.
The authors conclude that saffron as well as exposure to extremely low frequency magnetic fields could reduce the gene expression level of the vascular endothelial growth factor 2 in human breast cancer cells.