研究のタイプ: 医学/生物学の研究 (experimental study)

[電磁放射の影響を受けたラットの肝臓の構造学的および超微細構造学的研究] med./bio.

Structural and Ultrastructural Study of Rat Liver Influenced by Electromagnetic Radiation.

掲載誌: J Toxicol Environ Health A 2015; 78 (6): 353-356

この研究は、成獣ラット電磁界ばく露を与え(2.45GHz、電力密度2.8mW/cm2、1日3時間、3週間)、最後のばく露終了の3時間後に得た肝臓組織の標本を組織学的に検査した。その結果、肝小葉の中央に中程度の充血、肝類洞の拡張、小さな炎症性病巣が見られた;肝細胞の構造に変化はなかった、などの所見を報告している。

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研究目的(著者による)

The effects of exposure of rats to a pulsed 2.45 GHz electromagnetic field on the structure and ultrastructure of the liver should be investigated.

詳細情報

40 rats were divided into 2 groups (n=20 each): 1) control group and 2) exposure to the electromagnetic field. All animals were anesthetized and examined 3 hours after the last exposure session.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 2.45 GHz
ばく露時間: continuous for 3 h/day for 3 weeks

ばく露1

主たる特性
周波数 2.45 GHz
タイプ
  • electromagnetic field
波形
  • pulsed
ばく露時間 continuous for 3 h/day for 3 weeks
ばく露装置
ばく露の発生源/構造
  • 詳細不明
チャンバの詳細 purpose-designed chamber
パラメータ
測定量 種別 Method Mass 備考
電力密度 2.8 mW/cm² mean - - -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム(著者による)

Microscopy showed a slightly increased blood flow, dilatation of liver sinusoids and small inflammatory foci in the centers of liver lobules in the exposure group compared to the control group. The morphology of hepatocytes was not altered and all observed changes were classified as moderate.
Electron microscopy of hepatocytes revealed more vesicles, lipid droplets and growth of the smooth endoplasmic reticulum in cells of the exposure group compared to the control group. Occasionally, necrotic cells were found in the exposure group but not in the control group.
The authors conclude that exposure of rats to a pulsed 2.45 GHz electromagnetic field could have adverse effects on the liver.

研究の種別:

研究助成

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