研究のタイプ: 医学/生物学の研究 (experimental study)

[マイクロ波放射を受けたラットの肝臓に対するメラトニンの影響] med./bio.

The effect of melatonin on the liver of rats exposed to microwave radiation.

掲載誌: Bratisl Lek Listy 2015; 116 (2): 96-100

この研究は、マイクロ波(MWs)放射を受けたラット肝臓に、メラトニン(Mel:2mg/kgの腹腔内投与)の好ましい効果があるか否かを調べた。6週齢Wister雄ラット(n=84)を4群に分けた:対照群(生食投与)、Mel群、MWs群、MWs+Mel群。マイクロ波(900MHz、100-300μT、54-160V/m)は1日4時間、20、40、60日間のばく露とした。効果を酸化ストレスパラメータ、カタラーゼキサンチン酸化酵素デオキシリボヌクレアーゼの活性で評価した。結果として、メラトニンマイクロ波ばく露を受けた肝臓におけるある種の抗酸化作用に影響した、と報告している。

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研究目的(著者による)

The effects of exposure of rats to a 900 MHz electromagnetic field and co-exposure to melatonin on oxidative stress in the liver should be investigated.

詳細情報

84 rats were divided into 4 groups (n=21 each): 1) control group, 2) administration of melatonin, 3) exposure to microwaves, 4) administration of melatonin and exposure to microwaves. Seven animals of each group were sacrificed and examined after 20, 40 and 60 days of exposure, respectively.
2 mg/kg body weight melatonin was administered intraperitoneally every morning in groups 2 and 4. Animals of the control group received an equal volume of isotonic saline solution.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 900 MHz
Modulation type: CW
ばく露時間: continuous for 4h/day for 20, 40 or 60 days
  • 磁束密度: 4.86 µT minimum (according to abstract 100 µT (?))
  • 磁束密度: 8.69 µT maximum (according to abstract 300 µT (?))
  • 電界強度: 9.88 V/m minimum (according to abstract 54 V/m (?))
  • 電界強度: 18.356 V/m maximum (according to abstract 160 V/m (?))
  • SAR: 0.089 W/g mean (whole body)

ばく露1

主たる特性
周波数 900 MHz
タイプ
  • electromagnetic field
特性
  • near field
ばく露時間 continuous for 4h/day for 20, 40 or 60 days
Additional information GSM frequency band-mobile transmitting signal
Modulation
Modulation type CW
ばく露装置
ばく露の発生源/構造
  • セルラ-電話
チャンバの詳細 plastic cage without metallic fittings
ばく露装置の詳細 rats placed in plastic cage containing a mobile phone (Nokia 3110) with antenna positioned downwards; animals were able to move freely during exposure
パラメータ
測定量 種別 Method Mass 備考
磁束密度 4.86 µT minimum 測定値 - according to abstract 100 µT (?)
磁束密度 8.69 µT maximum 測定値 - according to abstract 300 µT (?)
電界強度 9.88 V/m minimum 測定値 - according to abstract 54 V/m (?)
電界強度 18.356 V/m maximum 測定値 - according to abstract 160 V/m (?)
SAR 0.089 W/g mean 推定値 whole body -

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The lipid peroxidation was significantly increased in group 3 (exposure to microwaves) compared to the control group after 40 and 60 days of exposure. At the same time, it was significantly reduced in group 4 (melatonin + microwaves) compared to group 3.
Moreover, protein oxidation was significantly increased after 20, 40 and 60 days, catalase and xanthine oxidase enzyme activity were significantly increased after 40 and 60 days and the enzyme activity of alkaline deoxyribonuclease I was significantly increased after 60 days of exposure in group 3 compared to the control group and group 2 (melatonin only).
The authors conclude that exposure of rats to a 900 MHz electromagnetic field could cause oxidative stress in the liver and that melatonin might have an antioxidant effect by reducing lipid peroxidation.

研究の種別:

研究助成

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