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The effects of exposure of rats to a 900 MHz electromagnetic field and co-exposure to melatonin on oxidative stress in the liver should be investigated.
84 rats were divided into 4 groups (n=21 each): 1) control group, 2) administration of melatonin, 3) exposure to microwaves, 4) administration of melatonin and exposure to microwaves. Seven animals of each group were sacrificed and examined after 20, 40 and 60 days of exposure, respectively.
2 mg/kg body weight melatonin was administered intraperitoneally every morning in groups 2 and 4. Animals of the control group received an equal volume of isotonic saline solution.
Modulation type: CW
ばく露時間: continuous for 4h/day for 20, 40 or 60 days
|チャンバの詳細||plastic cage without metallic fittings|
|ばく露装置の詳細||rats placed in plastic cage containing a mobile phone (Nokia 3110) with antenna positioned downwards; animals were able to move freely during exposure|
|磁束密度||4.86 µT||minimum||測定値||-||according to abstract 100 µT (?)|
|磁束密度||8.69 µT||maximum||測定値||-||according to abstract 300 µT (?)|
|電界強度||9.88 V/m||minimum||測定値||-||according to abstract 54 V/m (?)|
|電界強度||18.356 V/m||maximum||測定値||-||according to abstract 160 V/m (?)|
|SAR||0.089 W/g||mean||推定値||whole body||-|
The lipid peroxidation was significantly increased in group 3 (exposure to microwaves) compared to the control group after 40 and 60 days of exposure. At the same time, it was significantly reduced in group 4 (melatonin + microwaves) compared to group 3.
Moreover, protein oxidation was significantly increased after 20, 40 and 60 days, catalase and xanthine oxidase enzyme activity were significantly increased after 40 and 60 days and the enzyme activity of alkaline deoxyribonuclease I was significantly increased after 60 days of exposure in group 3 compared to the control group and group 2 (melatonin only).
The authors conclude that exposure of rats to a 900 MHz electromagnetic field could cause oxidative stress in the liver and that melatonin might have an antioxidant effect by reducing lipid peroxidation.