研究のタイプ: 医学／生物学の研究 (experimental study)

[915MHz放射へのばく露はソラマメの根端に小核を誘発する] med./bio.

Exposure to 915 MHz radiation induces micronuclei in Vicia faba root tips

著者: Gustavino B, Carboni G, Petrillo R, Paoluzzi G, Santovetti E, Rizzoni M
掲載誌: Mutagenesis 2016; 31 (2): 187-192
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この研究は、TEMセル内の制御された条件下で携帯電話の無線電磁界（RF-EMF）のばく露を受けたソラマメの二次側根での小核（MN）頻度を測定することにより、RF-EMFの突然変異原作用を調べた。RF-EMFばく露は、915MHz連続波、異なる電力密度（23、35、46W/m2）で、それぞれ72時間与えた。熱量法で測定した比吸収率（SAR）は0.4-1.5W/kgの範囲であった。実験は独立的に3回繰り返した。その結果、MN頻度は擬似ばく露群に比べ、最小SARレベルで2.3倍、最大SARレベルで7倍に上昇した、と報告している。

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研究目的（著者による）

The genotoxic effects of exposure of broad bean seedlings (Vicia faba) to a 915 MHz electromagnetic field should be investigated.

詳細情報

Seedlings were divided into the following groups: exposure to a 1) 1.5 W, 2) 2.3 W and 3) 3 W electromagnetic field and 4) sham exposure. A positive control was conducted.
Three independent experiments were performed and in each experiment 15 root tips and 5000 cells/tip were investigated in each group by different operators.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 915 MHz
Modulation type: CW
ばく露時間: continuous for 72 hours
ばく露2: 915 MHz
Modulation type: CW
ばく露時間: continuous for 72 hours
ばく露3: 915 MHz
Modulation type: CW
ばく露時間: continuous for 72 hours

ばく露1

主たる特性
周波数 915 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 72 hours
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
チャンバの詳細 plastic containers (101 Œ 74 mm)
ばく露装置の詳細 TEM was made of copper clad FR-4 plates; the sides of the cell were left open to simplify access; tapered walls were used to join the central region of the cell, 450 mm long, to the input and output coaxial connectors; whole system was kept inside a thermostatic cabinet with a constant temperature of 20°C in the dark
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電力 1.5 W mean 測定値 - ± 0.1 W
電力密度 23 W/m² mean 計算値 - ± 1.5 W
SAR 0.4 W/kg minimum 推定値 - -
Additional parameter details

point SAR inside the sample volume were highly non-uniform, the maximum value being typically about five times the average

ばく露2

主たる特性
周波数 915 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 72 hours
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電力 2.3 W mean 測定値 - ± 0.1 W
電力密度 35.2 W/m² mean 計算値 - ± 1.5 W
Additional parameter details

no explicit specifications on SAR of this group (between 0,4 and 1,6 W/kg); point SAR inside the sample volume were highly non-uniform, the maximum value being typically about five times the average

ばく露3

主たる特性
周波数 915 MHz
タイプ
  • electromagnetic field
ばく露時間 continuous for 72 hours
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
Sham exposure A sham exposure was conducted.
パラメータ
測定量 値 種別 Method Mass 備考
電力 3 W mean 測定値 - ± 0.2 W
電力密度 46 W/m² mean 計算値 - ± 3.1W
SAR 1 W/kg minimum 推定値 - -
SAR 1.6 W/kg maximum 推定値 - -
Additional parameter details

point SAR inside the sample volume were highly non-uniform, the maximum value being typically about five times the average

Reference articles

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
調査の時期:
  • ばく露後

研究の主なアウトカム（著者による）

The micronucleus frequency was significantly increased in all exposure groups (group 1-3) compared to the sham exposure group (group 4). The highest value was measured in group 3, showing a 7-fold higher value than the sham exposure group.
The authors conclude that exposure of broad bean seedlings (Vicia faba) to a 915 MHz electromagnetic field could have genotoxic effects.

研究の種別:

研究助成

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