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The neurotoxic effects of exposure to a 50 Hz magnetic field on the development of primary rat cortical neurons should be investigated.
Cells were divided into the following groups: exposure to a magnetic field of 1) 1 µT, 2) 10 µT, 3) 100 µT, 4) 1000 µT and 5) sham exposure.
All data were derived from at least 3 independent experiments.
|ばく露装置の詳細||double copper wired solenoid coils fitted into an incubator; coils consisted of one continuous copper conductor; the system generated AC and DC vertical field components|
|Sham exposure||A sham exposure was conducted.|
|Additional information||sham exposed cells were placed in a second incubator fitted with the same double copper wired solenoid coils, but switched off|
|磁束密度||1 µT||effective value||測定値||-||-|
The basal intracellular calcium concentration (unstimulated) was slightly but significantly decreased in group 4 (1000 µT) compared to the sham exposure group. The stimulated intracellular calcium concentration was significantly increased in group 1 (1 µT) and significantly decreased in group 3 (100 µT) and group 4 compared to the sham exposure group.
The axon outgrowth was significantly increased in group 4 compared to the sham exposure group.
Exposure to the magnetic field had no effect on cell viability and the electrical activity of the cells.
The authors conclude that exposure to a 50 Hz magnetic field has only limited neurotoxic effects on the development of primary rat cortical neurons in the case of strong fields.