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The effects of exposure to a pulsed 50 Hz magnetic field on bone formation and lipid metabolism and the underlying signal pathways should be investigated in a rat osteoporosis model.
Glucocorticoid-induced osteoporosis should be investigated. Therefore, all rats, except for the control group (group 4, see below), were injected with dexamethasone sodium phosphate injection (2.5 mg/kg body weight) into their right haunch muscles twice a week, 12 weeks prior to (sham) exposure to the pulsed magnetic field.
Rats were divided into 4 groups (n=10 each): 1) exposure to the pulsed magnetic field, 2) sham exposure and daily oral calcium supplement (56.25 mg/kg body weight), 3) only sham exposure, 4) sham exposed control group.
Modulation type: pulsed
ばく露時間: 40 minutes/day for 12 weeks
|ばく露時間||40 minutes/day for 12 weeks|
|Pulse width||200 µs|
|Sham exposure||A sham exposure was conducted.|
After exposure to the pulsed magnetic field for 12 weeks (group 1), the whole body bone mineral density was significantly increased, serum lipid levels were significantly decreased and trabecular bone (osseus tissue) in vertebra was significantly thicker compared to sham exposed GIOP rats (group 3).
The gene expressions and/or protein expressions of Wnt10b, LRP5, beta-catenin, OPG and Runx2 were significantly upregulated and Axin2, RANKL, PPAR-gamma, C/EBP-alpha, FABP4 and Dkk-1 were significantly downregulated in group 1 compared to group 3.
The authors conclude that exposure to a pulsed 50 Hz magnetic field might prevent bone loss and improve lipid metabolism disorders in osteoporosis model rats via the Wnt signaling pathway.