研究のタイプ: 医学／生物学の研究 (experimental study)

[神経機能と行動：関連の定義] med./bio.

Neural function and behavior: defining the relationship

著者: Frey AH, Feld SR, Frey B
掲載誌: Ann N Y Acad Sci 1975; 247: 433-439
RISフォーマットで参考文献をダウンロード

この論文は、AH Freyの研究室の長年の研究テーマである、高周波エネルギーの影響についてのレビューである。ネコの脳の誘発電位、ネコやサルでの条件付け反応、カエルでの心臓不整脈、ネコやヒトでの聴覚現象などの研究について紹介している。また、RFエネルギーが生物学的システム、特に神経系に与える影響一般について、可能性のあるメカニズムの候補を種々提案し、議論している。

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研究目的(acc. to editor)

To study the effects of pulsed irradiation, continuous wave (CW) irradiation, and sham irradiation on the behavior and blood-brain barrier permeability of rats and to define the relationship between neural function and behavior.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 1.2 GHz
Modulation type: pulsed
ばく露時間: 4 x 30 min
ばく露2: 1.2 GHz
Modulation type: CW
ばく露時間: 4 x 30 min
ばく露3: 1.2 GHz
Modulation type: pulsed
ばく露時間: 30 min
ばく露4: 1.2 GHz
Modulation type: CW
ばく露時間: 30 min

General information

18 female rats each were assigned to either pulse, continous wave or sham exposure group.

ばく露1

主たる特性
周波数 1.2 GHz
タイプ
  • electromagnetic field
ばく露時間 4 x 30 min
Modulation
Modulation type pulsed
Pulse width 500 µs
Packets per second 1,000
Additional information

Each pulse had a rise time of 1 µs followed by exponential decay to less than 1/3 pulse amplitude at pulse off.
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 White polystyrene shuttle box divided in half by a lower hurdle. One half was shielded from radio frequency
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 21 W/m² peak 推定値 - -
電力密度 2 W/m² mean 測定値 - -

ばく露2

主たる特性
周波数 1.2 GHz
タイプ
  • electromagnetic field
ばく露時間 4 x 30 min
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
  • E1と同じ装置
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 2.4 W/m² mean 測定値 - -

ばく露3

主たる特性
周波数 1.2 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 30 min
Modulation
Modulation type pulsed
Pulse width 500 µs
Packets per second 1,000
Additional information

Each pulse had a rise time of 1 µs followed by exponential decay to less than 1/3 pulse amplitude at pulse off.
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 Unconscoius animals (by sodium pentobarbital injection) lay on a block of Eccosorb energy absorber in five different positions within the chamber
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 21 W/m² peak 推定値 - -
電力密度 2 W/m² mean 測定値 - -

ばく露4

主たる特性
周波数 1.2 GHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 30 min
Modulation
Modulation type CW
ばく露装置
ばく露の発生源／構造
ばく露装置の詳細 Unconscoius animals (by sodium pentobarbital injection) lay on a block of Eccosorb energy absorber in five different positions within the chamber
パラメータ
測定量 値 種別 Method Mass 備考
電力密度 24 W/m² mean 測定値 - -

ばく露を受けた生物:

方法 影響評価項目／測定パラメータ／方法

研究対象とした生物試料:
研究対象とした臓器系:
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム（著者による）

An association between changes in behavior and in brain permeability was found. Also a difference in effectiveness of pulsed and continuous energy on behavior and brain permeability was found. The differences among groups in the behavior experiment were significant the last 2 days: the pulse-irradiated group spent 30%, the sham-irradiated group 52%, and the CW-irradiated group 64% of their time in the unshielded half of the box. The difference between the pulsed group and the sham group was significant, and the difference between the pulsed group and the CW group was also significant. However, the difference between the CW-exposed group and the sham-exposed group was not significant. The data of the brain permeability experiment indicate that irradiation of a small mammal with low-power radiofrequency energy affects the brain barriers. It appears that pulsed energy is significantly more effective than CW energy.

研究の種別:

研究助成

Replication studies