研究のタイプ: 医学/生物学の研究 (experimental study)

[E-mu-Pim1トランスジェニックマウスを898.4MHzのマイクロ波に長期間ばく露してもリンパ腫発生率は増加しない] med./bio.

Long-term exposure of E-mu-Pim1 transgenic mice to 898.4 MHz microwaves does not increase lymphoma incidence.

掲載誌: Radiat Res 2002; 158 (3): 357-364

この研究は、GSM電磁界の長期ばく露リンパ腫の発生に影響するか否かをマウス実験で調べた。合計120匹のE mu-Pim1ヘテロ接合マウスと120匹の野生型マウスに、それぞれ、観覧車型のGSM電磁界(898.4 MHzの変調波)ばく露システムから4つのばく露レベル(SAR値0.25、1.0、2.0、4.0 W / kg)のどれか1つでのばく露を、最大104週間、1時間/日、5日/週、継続して与えた。その他に、120匹のヘテロ接合性マウスと120匹の野生型マウスからなる擬似ばく露群、および非拘束陰性対照群を用いた。また、独立した別の実験により、上記実験におけるばく露非熱的レベルであることを確認した。その結果、いずれのばく露レベルにおいても、ばく露群と擬似ばく露群の間に、リンパ腫発生率に有意差はなかった;4つのばく露レベルを用いた実験で、用量反応関係は見出されなかった、と報告している。参考として、以前の研究(Repacholi et al。、Radiat。Res。147、631-640、1997)では、リンパ腫を起こしやすい性質を持つマウスに、900 MHz RF放射ばく露レベルは1つ)の長期ばく露を与え、結果として、擬似ばく露群と比較して、非リンパ芽球性リンパ腫発生率が有意に増加したことが報告されていることに言及している。

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研究目的(著者による)

To test whether exposure to 0.25, 1.0, 2.0 and 4.0 W/kg of global system for mobile communication (GSM)-modulated radiofrequency fields increased tumor incidence in Eµ-Pim1 transgenic heterozygous mice.

詳細情報

A total of 120 heterozygous and 120 wild-type mice were exposed at each of the exposure levels. 120 mice of each strain were sham-exposed and there were 120 freely moving negative control animals of each strain. 30 heterozygotes and 30 wild-type mice were used as positive controls. 100 sentinel mice were used for health monitoring purposes.

影響評価項目

ばく露

ばく露 パラメータ
ばく露1: 898.4 MHz
Modulation type: pulsed
ばく露時間: repeated daily exposure for 1 h/day, 5 days/week for up to 104 weeks
  • SAR: 0.25 W/kg unspecified (unspecified)
  • SAR: 1 W/kg unspecified (unspecified)
  • SAR: 2 W/kg unspecified (unspecified)
  • SAR: 4 W/kg unspecified (unspecified)

ばく露1

主たる特性
周波数 898.4 MHz
タイプ
  • electromagnetic field
特性
  • far field
ばく露時間 repeated daily exposure for 1 h/day, 5 days/week for up to 104 weeks
Modulation
Modulation type pulsed
Pulse width 0.6 ms
Repetition frequency 217 Hz
ばく露装置
ばく露の発生源/構造
Distance between exposed object and exposure source 44 cm
チャンバの詳細 The exposure systems were radial electromagnetic cavities (''Ferris wheels'') and have been described in the reference article. The mice were exposed or sham-exposed in a total of 15 exposure systems (three at each exposure level including shams) in five exposure rooms.
ばく露装置の詳細 Each of the 15 exposure systems consisted of a cylindrical parallel plate arrangement with mice restrained individually in 40 clear Perspex tubes arranged radially at a distance of 44 cm around a dipole antenna. Mice were loaded into the exposure systems using a two-level randomization supplied by the statistician. Mice sent for necropsy were replaced by phantoms that were both tissue-equivalent and had the average weight of the remaining mice in the cage to maintain constant dosimetry.
Additional information The study was double-blinded. A total of 120 heterozygous and 120 wild-type mice were exposed at each exposure level; 120 mice of each strain were sham-exposed; and there were 120 freely moving negative control mice of each strain that were only transported to the exposure rooms and immediately back to their home rooms. Thirty heterozygotes and 30 wild-type mice were used as positive controls. They were injected with ethylnitrosourea (pH 5.0) at 50 mg/kg body weight and sham-exposed. One hundred sentinel mice were also used for health monitoring purposes so that a total of 1600 mice entered the study.
パラメータ
測定量 種別 Method Mass 備考
SAR 0.25 W/kg unspecified 指定なし unspecified -
SAR 1 W/kg unspecified 指定なし unspecified -
SAR 2 W/kg unspecified 指定なし unspecified -
SAR 4 W/kg unspecified 指定なし unspecified -

Reference articles

  • Balzano Q et al. (2000): [900 MHzでの動物実験で正確に全身平均SARを決定するための効率的なRFばく露装置]

ばく露を受けた生物:

方法 影響評価項目/測定パラメータ/方法

研究対象とした生物試料:
研究対象とした臓器系:
  • 脳/腫瘍
  • thymus, spleen, lymph nodes, bone marrow in sternum and ribs, lung, heart, liver, kidney, small and large intestine, eyes
調査の時期:
  • ばく露中
  • ばく露後

研究の主なアウトカム(著者による)

The results showed no significant difference in the incidence of lymphomas between exposed and sham-exposed groups at any of the exposure levels. No dose-response effect was found.

研究の種別:

研究助成

Replicated studies

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