Study type: Medical/biological study (experimental study)

Gene expression does not change significantly in C3H 10T(1/2) cells after exposure to 847.74 CDMA or 835.62 FDMA radiofrequency radiation. med./bio.

Published in: Radiat Res 2006; 165 (6): 626-635

Aim of study (acc. to author)

To study whether FDMA or CDMA modulated radiofrequency irradiations induce changes in gene expression in mouse cells.

Background/further details

Cells exposed to 0.68 Gy of X rays were used as positive controls.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 835.62 MHz
Exposure duration: continuous for 24 h
  • power density: 860 W/m² average over time
  • SAR: 5 W/kg average over time (± 2.1 W/kg)
Exposure 2: 847.74 MHz
Exposure duration: continuous for 24 h
  • power density: 950 W/m² average over time
  • SAR: 5 W/kg average over time (± 2.1 W/kg)

Exposure 1

Main characteristics
Frequency 835.62 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 24 h
Additional info FDMA
Modulation
Modulation type cf. additional info
Additional info

FDMA

Exposure setup
Exposure source
Chamber A detailed description of the radial transmission line (RTL) irradiator and its environmental controls has been given in several publications (see reference articles).
Setup The culture flasks were distributed angularly around the antenna with their centers located at a radius of 29.2 cm.
Sham exposure A sham exposure was conducted.
Additional info The flasks for simultaneous sham exposure were handled in the same way as the flasks exposed to RF radiation but RTLs were not connected to an RF field source.
Parameters
Measurand Value Type Method Mass Remarks
power density 860 W/m² average over time measured - -
SAR 5 W/kg average over time measured - ± 2.1 W/kg

Exposure 2

Main characteristics
Frequency 847.74 MHz
Type
Charakteristic
  • guided field
Exposure duration continuous for 24 h
Additional info CDMA
Modulation
Modulation type cf. additional info
Additional info

CDMA

Exposure setup
Exposure source
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
power density 950 W/m² average over time measured - -
SAR 5 W/kg average over time measured - ± 2.1 W/kg

Reference articles

  • Pickard WF et al. (2000): Experimental and numerical determination of SAR distributions within culture flasks in a dielectric loaded radial transmission line.
  • Moros EG et al. (1999): The radial transmission line as a broad-band shielded exposure system for microwave irradiation of large numbers of culture flasks.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The 24 h exposures to FDMA or CDMA radiofrequency irradiation at 5 W/kg had no statistically significant effect on gene expression.

Study character:

Study funded by

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