Study type: Medical/biological study (experimental study)

Mobile phone radiation causes changes in gene and protein expression in human endothelial cell lines and the response seems to be genome- and proteome-dependent. med./bio.

Published in: Proteomics 2006; 6 (17): 4769-4780

Aim of study (acc. to author)

To study the effects of 900 MHz GSM mobile phone irradiation on the gene and protein expression in two closely related human endothelial cell lines.

Background/further details

Gene expression changes were examined in three experiments and investigation of protein expression changes were replicated in ten experiments.
The work is part of the REFLEX project (Risk Evaluation of Potential Environmental Hazards From Low Energy Electromagnetic Field Exposure Using Sensitive in vitro Methods), funded by the European Union.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 1 h

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 1 h
Modulation
Modulation type pulsed
Additional info

GSM signal

Exposure setup
Setup Cells were irradiated with a simulated mobile phone microwave radiation as described in [Leszczynski et al., 2002].
Sham exposure A sham exposure was conducted.
Additional info The temperature of the cells and the culture medium remained at 37 ± 0.2°C throughout the exposure period.
Parameters
Measurand Value Type Method Mass Remarks
SAR 2.8 W/kg mean measured and calculated - -

Reference articles

  • Leszczynski D et al. (2002): Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanism for cancer- and blood-brain barrier-related effects.

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that gene and protein expression are altered in both cell lines in response to mobile phone irradiation. Furthermore, different genes and different proteins were affected by the same exposure in both cell lines. This suggest that under these experimental conditions the cell responses might be genome- and proteome-dependent.

Study character:

Study funded by

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