Study type: Medical/biological study (experimental study)

Brain proteome response following whole body exposure of mice to mobile phone or wireless DECT base radiation. med./bio.

Published in: Electromagn Biol Med 2012; 31 (4): 250-274

Aim of study (acc. to author)

To study the effects of two sources of electromagnetic fields (mobile phone and DECT) on the proteome of cerebellum, hippocampus, and frontal lobe in mice following long-term whole body irradiation.

Background/further details

18 male mice were divided into three groups (n=6 per proup): 1) mobile phone exposure group, 2) DECT exposure group, 3) sham exposure group.

Endpoint

Exposure

Exposure Parameters
Exposure 1: 900 MHz
Modulation type: pulsed
Exposure duration: continuous for 3 h/day for 8 months
Exposure 2: 1,880–1,900 MHz
Exposure duration: continuous for 8 h/day during 8 months

Exposure 1

Main characteristics
Frequency 900 MHz
Type
Exposure duration continuous for 3 h/day for 8 months
Modulation
Modulation type pulsed
Exposure setup
Exposure source
Setup mobile phone placed under the semi-Faraday cage (425 x 266 x 155 mm) with one open side to allow the mobile phone irradiation to enter the cage; radio playing during exposure to mimic talking
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 15 V/m minimum measured - inside the cage
electric field strength 22 V/m maximum measured - inside the cage
SAR 0.17 W/kg minimum calculated whole body -
SAR 0.37 W/kg maximum calculated whole body -

Exposure 2

Main characteristics
Frequency 1,880–1,900 MHz
Type
Exposure duration continuous for 8 h/day during 8 months
Exposure setup
Exposure source
Setup DECT base station scanning all 10 allocated channels without communication to a mobile device; placed close to the semi-Faraday cage (425 x 266 x 155 mm) with one open side; radio playing during exposure
Sham exposure A sham exposure was conducted.
Parameters
Measurand Value Type Method Mass Remarks
electric field strength 4 V/m minimum measured - inside the cage
electric field strength 6 V/m maximum measured - inside the cage
SAR 0.012 W/kg minimum calculated whole body -
SAR 0.028 W/kg maximum calculated whole body -

Reference articles

Exposed system:

Methods Endpoint/measurement parameters/methodology

Investigated system:
Investigated organ system:
Time of investigation:
  • after exposure

Main outcome of study (acc. to author)

The data showed that long-term exposure to both electromagnetic field sources altered significantly the expression of 143 proteins in total (neural function related proteins, heat shock proteins, cytoskeletal proteins, proteins of the brain metabolism). Most of these changes occured in the hippocampus and the majority of the changes was induced by mobile phone exposure. Western blot analysis confirmed the differential expression of two upregulated proteins (apoE and GFAP) and one downregulated protein (GMF).

Study character:

Study funded by

Related articles